The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. Previously, we have developed high conductance dielectrophoretic (HC-DEP) microarray devices which allowed cfc-DNA, cellular nanoparticles (mitochondria, etc.), nanoparticles and virus to be rapidly isolated from undiluted whole blood. Now we have developed novel capillary tube and pipette tip DEP devices which can be used to isolate cfc-DNA directly from a few microliters of whole blood. An AC voltage from 50-150 volts is applied at frequencies of 5kHz-10kHz which causes cfc-DNA to become concentrated on the tip of the device. The material captured on the tip can then be transferred to a collection tube for further analysis (PCR, genotyping, sequencing). The new HC-DEP devices are being used to collect cfc-DNA from Chronic Lymphocytic Leukemia (CLL) whole blood patient samples. Blood sample to PCR is achieved in less than twenty minutes. HC-DEP sets the stage for new "seamless" sample to answer diagnostic systems which will allow a variety of important cancer and other disease biomarkers to be rapidly isolated and analyzed directly from blood and other clinical samples.