New frontiers in translational research in neuro-oncology and the blood-brain barrier

Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting

Nancy Doolittle, Lauren E. Abrey, W. Archie Bleyer, Steven Brem, Thomas P. Davis, Paula Dore-Duffy, Lester R. Drewes, Walter A. Hall, John M. Hoffman, Agnieszka Korfel, Robert Martuza, Leslie Muldoon, David Peereboom, Darryl R. Peterson, Samuel D. Rabkin, Quentin Smith, Glen H J Stevens, Edward Neuwelt

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to the CNS, neuroimaging, angiogenesis, immunotherapy, and gene therapy, as well as glioma, primary CNS lymphoma, and metastases to the CNS were discussed. Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements.

Original languageEnglish (US)
Pages (from-to)421-428
Number of pages8
JournalClinical Cancer Research
Volume11
Issue number2 I
StatePublished - Jan 15 2005

Fingerprint

Annual Reports
Translational Medical Research
Blood-Brain Barrier
Central Nervous System
Central Nervous System Agents
Pericytes
Organized Financing
Central Nervous System Diseases
Neuroimaging
Brain Neoplasms
Glioma
Neuroglia
Genetic Therapy
Immunotherapy
Cell Biology
Lymphoma
Endothelial Cells
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

New frontiers in translational research in neuro-oncology and the blood-brain barrier : Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting. / Doolittle, Nancy; Abrey, Lauren E.; Bleyer, W. Archie; Brem, Steven; Davis, Thomas P.; Dore-Duffy, Paula; Drewes, Lester R.; Hall, Walter A.; Hoffman, John M.; Korfel, Agnieszka; Martuza, Robert; Muldoon, Leslie; Peereboom, David; Peterson, Darryl R.; Rabkin, Samuel D.; Smith, Quentin; Stevens, Glen H J; Neuwelt, Edward.

In: Clinical Cancer Research, Vol. 11, No. 2 I, 15.01.2005, p. 421-428.

Research output: Contribution to journalArticle

Doolittle, N, Abrey, LE, Bleyer, WA, Brem, S, Davis, TP, Dore-Duffy, P, Drewes, LR, Hall, WA, Hoffman, JM, Korfel, A, Martuza, R, Muldoon, L, Peereboom, D, Peterson, DR, Rabkin, SD, Smith, Q, Stevens, GHJ & Neuwelt, E 2005, 'New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting', Clinical Cancer Research, vol. 11, no. 2 I, pp. 421-428.
Doolittle, Nancy ; Abrey, Lauren E. ; Bleyer, W. Archie ; Brem, Steven ; Davis, Thomas P. ; Dore-Duffy, Paula ; Drewes, Lester R. ; Hall, Walter A. ; Hoffman, John M. ; Korfel, Agnieszka ; Martuza, Robert ; Muldoon, Leslie ; Peereboom, David ; Peterson, Darryl R. ; Rabkin, Samuel D. ; Smith, Quentin ; Stevens, Glen H J ; Neuwelt, Edward. / New frontiers in translational research in neuro-oncology and the blood-brain barrier : Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting. In: Clinical Cancer Research. 2005 ; Vol. 11, No. 2 I. pp. 421-428.
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