New Findings in the Chromosome 13 Long-Arm Deletion Syndrome and Retinoblastoma

Ralph R. Weichselbaum, Z. Nicholas Zakov, Daniel M. Albert, Alan H. Friedman, John Nove, John B. Little

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiationinduced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.

Original languageEnglish (US)
Pages (from-to)1191-1198
Number of pages8
JournalOphthalmology
Volume86
Issue number6
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Ophthalmology

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