New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

Dexing Zeng, Qin Ouyang, Zhengxin Cai, Xiang Qun Xie, Carolyn J. Anderson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with 64Cu under mild conditions in high specific activity. DBCO-PEG 4-CB-TE1K1P was synthesized for conjugation to proteins, while Dde-CB-TE1K1P(tBu2)-OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalChemical Communications
Volume50
Issue number1
DOIs
StatePublished - Jan 4 2014
Externally publishedYes

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Chelating Agents
Radioisotopes
Peptides
Polyethylene glycols
Copper
Derivatives
Proteins
Radiopharmaceuticals
cyclam

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides. / Zeng, Dexing; Ouyang, Qin; Cai, Zhengxin; Xie, Xiang Qun; Anderson, Carolyn J.

In: Chemical Communications, Vol. 50, No. 1, 04.01.2014, p. 43-45.

Research output: Contribution to journalArticle

Zeng, Dexing ; Ouyang, Qin ; Cai, Zhengxin ; Xie, Xiang Qun ; Anderson, Carolyn J. / New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides. In: Chemical Communications. 2014 ; Vol. 50, No. 1. pp. 43-45.
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