New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

Dexing Zeng; Qin Ouyang; Zhengxin Cai; Xiang Qun Xie; Carolyn J. Anderson

doi:10.1039/c3cc45928d

New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

Dexing Zeng, Qin Ouyang, Zhengxin Cai, Xiang Qun Xie, Carolyn J. Anderson

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with ⁶⁴Cu under mild conditions in high specific activity. DBCO–PEG₄–CB-TE1K1P was synthesized for conjugation to proteins, while Dde–CB-TE1K1P(^tBu₂)–OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

Original language	English (US)
Pages (from-to)	43-45
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	1
DOIs	https://doi.org/10.1039/c3cc45928d
State	Published - Nov 26 2014
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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title = "New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides",

abstract = "A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with 64Cu under mild conditions in high specific activity. DBCO–PEG4–CB-TE1K1P was synthesized for conjugation to proteins, while Dde–CB-TE1K1P(tBu2)–OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.",

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AU - Zeng, Dexing

AU - Ouyang, Qin

AU - Cai, Zhengxin

AU - Xie, Xiang Qun

AU - Anderson, Carolyn J.

PY - 2014/11/26

Y1 - 2014/11/26

N2 - A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with 64Cu under mild conditions in high specific activity. DBCO–PEG4–CB-TE1K1P was synthesized for conjugation to proteins, while Dde–CB-TE1K1P(tBu2)–OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

AB - A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with 64Cu under mild conditions in high specific activity. DBCO–PEG4–CB-TE1K1P was synthesized for conjugation to proteins, while Dde–CB-TE1K1P(tBu2)–OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

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JF - Chemical Communications

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ER -

New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

Abstract

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