New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides

Dexing Zeng, Qin Ouyang, Zhengxin Cai, Xiang Qun Xie, Carolyn J. Anderson

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with 64Cu under mild conditions in high specific activity. DBCO–PEG4–CB-TE1K1P was synthesized for conjugation to proteins, while Dde–CB-TE1K1P(tBu2)–OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalChemical Communications
Volume50
Issue number1
DOIs
StatePublished - Nov 26 2014

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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