New concepts on the control of the onset of puberty

Sergio Ojeda, Alejandro Lomniczi, Ursula Sandau, Valerie Matagne

    Research output: Chapter in Book/Report/Conference proceedingChapter

    51 Citations (Scopus)

    Abstract

    The initiation of mammalian puberty requires an increased pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This increase is brought about by changes in transsynaptic and glial-neuronal communication. Coordination of these cellular interactions likely requires the participation of sets of genes hierarchically arranged within functionally connected networks. Using high throughput, genetic, molecular and bioinformatics strategies, in combination with a systems biology approach, three transcriptional regulators of the pubertal process have been identified, and the structure of at least one hypothalamic gene network has been proposed. A genomewide analysis of hypothalamic DNA methylation revealed profound changes in methylation patterns associated with the onset of female puberty. Pharmacological disruption of two epigenetic marks associated with gene silencing (DNA methylation and histone deacetylation) resulted in pubertal failure, instead of advancing the onset of puberty, suggesting that disruption of these two silencing mechanisms leads to activation of repressor genes whose expression would normally decrease at puberty. These observations suggest that the genetic underpinnings of puberty are polygenic rather than specified by a single gene, and that epigenetic mechanisms may provide coordination and transcriptional plasticity to this genetic network.

    Original languageEnglish (US)
    Title of host publicationPediatric Neuroendocrinology
    PublisherS. Karger AG
    Pages44-51
    Number of pages8
    Volume17
    ISBN (Print)9783805593038, 9783805593021
    DOIs
    StatePublished - Nov 24 2009

    Fingerprint

    Puberty
    DNA Methylation
    Epigenomics
    Systems Biology
    Gene Regulatory Networks
    Gene Silencing
    Computational Biology
    Gonadotropin-Releasing Hormone
    Neuroglia
    Histones
    Methylation
    Genes
    Hypothalamus
    Molecular Biology
    Pharmacology
    Gene Expression

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Ojeda, S., Lomniczi, A., Sandau, U., & Matagne, V. (2009). New concepts on the control of the onset of puberty. In Pediatric Neuroendocrinology (Vol. 17, pp. 44-51). S. Karger AG. https://doi.org/10.1159/000262527

    New concepts on the control of the onset of puberty. / Ojeda, Sergio; Lomniczi, Alejandro; Sandau, Ursula; Matagne, Valerie.

    Pediatric Neuroendocrinology. Vol. 17 S. Karger AG, 2009. p. 44-51.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ojeda, S, Lomniczi, A, Sandau, U & Matagne, V 2009, New concepts on the control of the onset of puberty. in Pediatric Neuroendocrinology. vol. 17, S. Karger AG, pp. 44-51. https://doi.org/10.1159/000262527
    Ojeda S, Lomniczi A, Sandau U, Matagne V. New concepts on the control of the onset of puberty. In Pediatric Neuroendocrinology. Vol. 17. S. Karger AG. 2009. p. 44-51 https://doi.org/10.1159/000262527
    Ojeda, Sergio ; Lomniczi, Alejandro ; Sandau, Ursula ; Matagne, Valerie. / New concepts on the control of the onset of puberty. Pediatric Neuroendocrinology. Vol. 17 S. Karger AG, 2009. pp. 44-51
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