New Concepts in Tuberculosis Host Defense

David M. Lewinsohn, Deborah A. Lewinsohn

Research output: Contribution to journalReview article

Abstract

Tuberculosis (TB) host defense depends on cellular immunity, including macrophages and adaptively acquired CD4+ and CD8+ T cells. More recently, roles for new immune components, including neutrophils, innate T cells, and B cells, have been defined, and the understanding of the function of macrophages and adaptively acquired T cells has been advanced. Moreover, the understanding of TB immunology elucidates TB infection and disease as a spectrum. Finally, determinates of TB host defense, such as age and comorbidities, affect clinical expression of TB disease. Herein, the authors comprehensively review TB immunology with an emphasis on new advances.

Original languageEnglish (US)
Pages (from-to)703-719
Number of pages17
JournalClinics in Chest Medicine
Volume40
Issue number4
DOIs
Publication statusPublished - Dec 2019

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Keywords

  • Adaptive immunity
  • Innate immunity
  • Macrophages
  • T cells
  • Trained immunity
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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