TY - JOUR
T1 - New Concepts in Tuberculosis Host Defense
AU - Lewinsohn, David M.
AU - Lewinsohn, Deborah A.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/12
Y1 - 2019/12
N2 - Tuberculosis (TB) host defense depends on cellular immunity, including macrophages and adaptively acquired CD4+ and CD8+ T cells. More recently, roles for new immune components, including neutrophils, innate T cells, and B cells, have been defined, and the understanding of the function of macrophages and adaptively acquired T cells has been advanced. Moreover, the understanding of TB immunology elucidates TB infection and disease as a spectrum. Finally, determinates of TB host defense, such as age and comorbidities, affect clinical expression of TB disease. Herein, the authors comprehensively review TB immunology with an emphasis on new advances.
AB - Tuberculosis (TB) host defense depends on cellular immunity, including macrophages and adaptively acquired CD4+ and CD8+ T cells. More recently, roles for new immune components, including neutrophils, innate T cells, and B cells, have been defined, and the understanding of the function of macrophages and adaptively acquired T cells has been advanced. Moreover, the understanding of TB immunology elucidates TB infection and disease as a spectrum. Finally, determinates of TB host defense, such as age and comorbidities, affect clinical expression of TB disease. Herein, the authors comprehensively review TB immunology with an emphasis on new advances.
KW - Adaptive immunity
KW - Innate immunity
KW - Macrophages
KW - T cells
KW - Trained immunity
KW - Tuberculosis
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U2 - 10.1016/j.ccm.2019.07.002
DO - 10.1016/j.ccm.2019.07.002
M3 - Review article
C2 - 31731979
AN - SCOPUS:85074707200
SN - 0272-5231
VL - 40
SP - 703
EP - 719
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 4
ER -