New concepts in the pathophysiology of oxygen metabolism during sepsis

A. A. Vlessis, R. K. Goldman, D. D. Trunkey

Research output: Contribution to journalReview article

57 Scopus citations


Sepsis is an intriguing pathological condition associated with many complex metabolic and physiological alterations. In this review a novel hypothesis in the pathophysiology of oxygen metabolism during sepsis is explored. It is proposed that the hypermetabolic response to sepsis results from enhanced reactive oxygen generation by phagocytes. Reactive oxygen detoxification by host enzyme systems subsequently leads to alterations in oxidative metabolism. The similarities between the metabolic consequences of reactive oxygen metabolism and the metabolic changes observed during sepsis are outlined. A unified concept is presented to help explain the pathophysiological changes in oxygen metabolism during sepsis.

Original languageEnglish (US)
Pages (from-to)870-876
Number of pages7
JournalBritish Journal of Surgery
Issue number7
StatePublished - Jul 1995


ASJC Scopus subject areas

  • Surgery

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