New approaches to design HIV-1 T-cell vaccines

Hélène Perrin, Glenda Canderan, Rafick Pierre Sékaly, Lydie Trautmann

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Purpose of review: Following the evidence that T-cell responses are crucial in the control of HIV-1 infection, vaccines targeting T-cell responses were tested in recent clinical trials. However, these vaccines showed a lack of efficacy. This review attempts to define the qualitative and quantitative features that are desirable for T-cell-induced responses by vaccines. We also describe strategies that could lead to achievement of this goal. Recent Findings: Using the yellow fever vaccine as a benchmark of an efficient vaccine, recent studies identified factors of immune protection and more importantly innate immune pathways needed for the establishment of long-term protective adaptive immunity. Summary: To prevent or control HIV-1 infection, a vaccine must induce efficient and persistent antigen-specific T cells endowed with mucosal homing capacity. Such cells should have the capability to counteract HIV-1 diversity and its rapid spread from the initial site of infection. To achieve this goal, the activation of a diversified innate immune response is critical. New systems biology approaches will provide more precise correlates of immune protection that will pave the way for new approaches in T-cell-based vaccines.

Original languageEnglish (US)
Pages (from-to)368-376
Number of pages9
JournalCurrent Opinion in HIV and AIDS
Volume5
Issue number5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • dendritic cell targeting
  • HIV-1 vaccine
  • protective T cell

ASJC Scopus subject areas

  • Immunology
  • Hematology
  • Oncology
  • Oncology(nursing)
  • Infectious Diseases
  • Virology

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