New agents for the prevention of opportunistic infections in haematopoietic stem cell transplant recipients

Gianna Zuccotti, Lynne Strasfeld, David M. Weinstock

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Over the past three decades, autologous and allogeneic haematopoietic stem cell transplants (HSCTs) have become effective treatments for a variety of malignant and nonmalignant conditions. Patients who undergo HSCT receive high doses of chemotherapy and/or radiation that induce a prolonged period of profound immunodeficiency, placing them at high risk for infection from a panoply of opportunistic organisms. Although supportive treatment for these patients has markedly improved, 10 - 20% of allogeneic HSCT recipients will ultimately succumb to infection. Joint guidelines to prevent opportunistic infection were released in 2000 by the Centers for Disease Control, the Infectious Diseases Society of America, and the American Society of Blood and Marrow Transplantation; however, treatment decisions for these patients are often based on limited studies or depend on institution-specific transplant protocols and antibiotic resistance patterns. This paper will discuss new agents for preventing bacterial, fungal and viral infections in HSCT recipients.

Original languageEnglish (US)
Pages (from-to)1669-1679
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Volume6
Issue number10
DOIs
StatePublished - Aug 1 2005

Keywords

  • Infection
  • Prophylaxis
  • Stem cell transplant

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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