TY - JOUR
T1 - Neutropenias following allogeneic bone marrow transplantation
T2 - Response to therapy with high-dose intravenous immunoglobulin
AU - Khouri, Issa F.
AU - Ippoliti, Cindy
AU - Gajewski, James
AU - Przepiorka, Donna
AU - Champlin, Richard E.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - Cytopenias following bone marrow transplantation may be severe and life-threatening. These have been described post-allogeneic Klumpp, 1991: Bone Marrow Transplant 8:159-171. or post-autologous bone marrow transplants Khouri et al., 1994: J Clin Oncol 12:749-758. as well as with peripheral blood stem cell transplantation Klumpp et al., 1992: Am J Hematol 41:215- 217. It can be immune mediated, associated on occasions with graft-versus- host disease (GVHD) Anasetti et al., 1989: Blood 4:1054-1058; however, in most cases, the underlying mechanism is uncertain. The treatment of post- transplant cytopenias is not well established, and they are often refractory to immunosuppressive therapy with steroids. Herein we describe two cases of neutropenia after allogeneic bone marrow transplantation that improved after therapy with high-dose intravenous immunoglobulin.
AB - Cytopenias following bone marrow transplantation may be severe and life-threatening. These have been described post-allogeneic Klumpp, 1991: Bone Marrow Transplant 8:159-171. or post-autologous bone marrow transplants Khouri et al., 1994: J Clin Oncol 12:749-758. as well as with peripheral blood stem cell transplantation Klumpp et al., 1992: Am J Hematol 41:215- 217. It can be immune mediated, associated on occasions with graft-versus- host disease (GVHD) Anasetti et al., 1989: Blood 4:1054-1058; however, in most cases, the underlying mechanism is uncertain. The treatment of post- transplant cytopenias is not well established, and they are often refractory to immunosuppressive therapy with steroids. Herein we describe two cases of neutropenia after allogeneic bone marrow transplantation that improved after therapy with high-dose intravenous immunoglobulin.
KW - neutropenias
KW - post ABMT and IVIG
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U2 - 10.1002/(SICI)1096-8652(199608)52:4<313::AID-AJH12>3.0.CO;2-E
DO - 10.1002/(SICI)1096-8652(199608)52:4<313::AID-AJH12>3.0.CO;2-E
M3 - Article
C2 - 8701951
AN - SCOPUS:0029737781
SN - 0361-8609
VL - 52
SP - 313
EP - 315
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 4
ER -