Neutropenias following allogeneic bone marrow transplantation: Response to therapy with high-dose intravenous immunoglobulin

Issa F. Khouri, Cindy Ippoliti, James Gajewski, Donna Przepiorka, Richard E. Champlin

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations

    Abstract

    Cytopenias following bone marrow transplantation may be severe and life-threatening. These have been described post-allogeneic Klumpp, 1991: Bone Marrow Transplant 8:159-171. or post-autologous bone marrow transplants Khouri et al., 1994: J Clin Oncol 12:749-758. as well as with peripheral blood stem cell transplantation Klumpp et al., 1992: Am J Hematol 41:215- 217. It can be immune mediated, associated on occasions with graft-versus- host disease (GVHD) Anasetti et al., 1989: Blood 4:1054-1058; however, in most cases, the underlying mechanism is uncertain. The treatment of post- transplant cytopenias is not well established, and they are often refractory to immunosuppressive therapy with steroids. Herein we describe two cases of neutropenia after allogeneic bone marrow transplantation that improved after therapy with high-dose intravenous immunoglobulin.

    Original languageEnglish (US)
    Pages (from-to)313-315
    Number of pages3
    JournalAmerican Journal of Hematology
    Volume52
    Issue number4
    DOIs
    StatePublished - 1996

    Keywords

    • neutropenias
    • post ABMT and IVIG

    ASJC Scopus subject areas

    • Hematology

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