Neutropenia after single-dose clindamycin for dental prophylaxis

Joseph Bubalo, Carolyn S. Blasdel, David T. Bearden

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    A 68-year-old man with stable chronic myelogenous leukemia received a single dose of clindamycin before having a tooth extracted. He was neutropenic 6 days later, with an absolute neutrophil count of 945 cells/mm3. His neutrophil count returned to normal within 2 weeks. Clindamycin has been implicated in drug-induced neutropenia; however, a review of the literature produced only three reports of this reaction. Only one provided the duration of the neutropenia. To our knowledge, this case report is only the second that provides the duration of the clindamycin-induced neutropenia. Clinicians should be made aware of this potential adverse event.

    Original languageEnglish (US)
    Pages (from-to)101-103
    Number of pages3
    JournalPharmacotherapy
    Volume23
    Issue number1
    DOIs
    StatePublished - Jan 1 2003

    Fingerprint

    Dental Prophylaxis
    Clindamycin
    Neutropenia
    Neutrophils
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Tooth
    Cell Count
    Pharmaceutical Preparations

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Neutropenia after single-dose clindamycin for dental prophylaxis. / Bubalo, Joseph; Blasdel, Carolyn S.; Bearden, David T.

    In: Pharmacotherapy, Vol. 23, No. 1, 01.01.2003, p. 101-103.

    Research output: Contribution to journalArticle

    Bubalo, Joseph ; Blasdel, Carolyn S. ; Bearden, David T. / Neutropenia after single-dose clindamycin for dental prophylaxis. In: Pharmacotherapy. 2003 ; Vol. 23, No. 1. pp. 101-103.
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