Neutralizing tumor-promoting chronic inflammation: A magic bullet?

Lisa M. Coussens, Laurence Zitvogel, A. Karolina Palucka

Research output: Contribution to journalReview article

555 Scopus citations

Abstract

There have been substantial advances in cancer diagnostics and therapies in the past decade. Besides chemotherapeutic agents and radiation therapy, approaches now include targeting cancer cell-intrinsic mediators linked to genetic aberrations in cancer cells, in addition to cancer cell-extrinsic pathways, especially those regulating vascular programming of solid tumors. More recently, immunotherapeutics have entered the clinic largely on the basis of the recognition that several immune cell subsets, when chronically activated, foster tumor development. Here, we discuss clinical and experimental studies delineating protumorigenic roles for immune cell subsets that are players in cancer-associated inflammation. Some of these cells can be targeted to reprogram their function, leading to resolution, or at least neutralization, of cancer-promoting chronic inflammation, thereby facilitating cancer rejection.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalScience
Volume339
Issue number6117
DOIs
StatePublished - Jan 18 2013

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