Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Joao Prola Netto; Jeffrey Iliff; Danica Stanimirovic; Kenneth A. Krohn; Bronwyn Hamilton; Csanad Varallyay; Seymur Gahramanov; Heike Daldrup-Link; Christopher D'Esterre; Berislav Zlokovic; Haris Sair; Yueh Lee; Saeid Taheri; Rajan Jain; Ashok Panigrahy; Daniel S. Reich; Lester R. Drewes; Mauricio Castillo; Edward A. Neuwelt

doi:10.1093/neuros/nyx357

Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A. Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher D'Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S. Reich, Lester R. Drewes, Mauricio Castillo, Edward A. Neuwelt

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

Original language	English (US)
Pages (from-to)	770-780
Number of pages	11
Journal	Neurosurgery
Volume	82
Issue number	6
DOIs	https://doi.org/10.1093/neuros/nyx357
State	Published - Jun 1 2018

Keywords

Blood-brain barrier
Imaging
Neurovascular unit

ASJC Scopus subject areas

Clinical Neurology
Surgery

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10.1093/neuros/nyx357

Cite this

Netto, J. P., Iliff, J., Stanimirovic, D., Krohn, K. A., Hamilton, B., Varallyay, C., Gahramanov, S., Daldrup-Link, H., D'Esterre, C., Zlokovic, B., Sair, H., Lee, Y., Taheri, S., Jain, R., Panigrahy, A., Reich, D. S., Drewes, L. R., Castillo, M., & Neuwelt, E. A. (2018). Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol. Neurosurgery, 82(6), 770-780. https://doi.org/10.1093/neuros/nyx357

Netto, JP, Iliff, J, Stanimirovic, D, Krohn, KA, Hamilton, B, Varallyay, C, Gahramanov, S, Daldrup-Link, H, D'Esterre, C, Zlokovic, B, Sair, H, Lee, Y, Taheri, S, Jain, R, Panigrahy, A, Reich, DS, Drewes, LR, Castillo, M & Neuwelt, EA 2018, 'Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol', Neurosurgery, vol. 82, no. 6, pp. 770-780. https://doi.org/10.1093/neuros/nyx357

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abstract = "Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.",

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author = "Netto, {Joao Prola} and Jeffrey Iliff and Danica Stanimirovic and Krohn, {Kenneth A.} and Bronwyn Hamilton and Csanad Varallyay and Seymur Gahramanov and Heike Daldrup-Link and Christopher D'Esterre and Berislav Zlokovic and Haris Sair and Yueh Lee and Saeid Taheri and Rajan Jain and Ashok Panigrahy and Reich, {Daniel S.} and Drewes, {Lester R.} and Mauricio Castillo and Neuwelt, {Edward A.}",

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doi = "10.1093/neuros/nyx357",

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AU - Netto, Joao Prola

AU - Iliff, Jeffrey

AU - Stanimirovic, Danica

AU - Krohn, Kenneth A.

AU - Hamilton, Bronwyn

AU - Varallyay, Csanad

AU - Gahramanov, Seymur

AU - Daldrup-Link, Heike

AU - D'Esterre, Christopher

AU - Zlokovic, Berislav

AU - Sair, Haris

AU - Lee, Yueh

AU - Taheri, Saeid

AU - Jain, Rajan

AU - Panigrahy, Ashok

AU - Reich, Daniel S.

AU - Drewes, Lester R.

AU - Castillo, Mauricio

AU - Neuwelt, Edward A.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

AB - Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

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KW - Imaging

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Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Abstract

Keywords

ASJC Scopus subject areas

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