Neurotrophin roles in retinal ganglion cell survival

Lessons from rat glaucoma models

Elaine Johnson, Ying Guo, William O. Cepurna, John Morrison

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The neurotrophin (NT) hypothesis proposes that the obstruction of retrograde transport at the optic nerve head results in the deprivation of neurotrophic support to retinal ganglion cells (RGC) leading to apoptotic cell death in glaucoma. An important corollary to this concept is the implication that appropriate enhancement of neurotrophic support will prolong the survival of injured RGC indefinitely. This hypothesis is, perhaps, the most widely recognized theory to explain RGC loss resulting from exposure of the eye to elevated intraocular pressure (IOP). Recent studies of NT signaling using rat glaucoma models, have examined the endogenous responses of the retina to pressure exposure as well as studies designed to augment NT signaling in order to rescue RGC from apoptosis following pressure-induced injury. The examination of these studies in this review reveals a number of consistent observations and provides direction for further investigations of this hypothesis.

Original languageEnglish (US)
Pages (from-to)808-815
Number of pages8
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Fingerprint

Retinal Ganglion Cells
Nerve Growth Factors
Glaucoma
Cell Survival
Pressure
Optic Disk
Intraocular Pressure
Retina
Cell Death
Apoptosis
Wounds and Injuries

Keywords

  • experimental glaucoma
  • intraocular pressure
  • neurotrophic factors
  • P75 neurotrophin receptor
  • TRK receptors

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Neurotrophin roles in retinal ganglion cell survival : Lessons from rat glaucoma models. / Johnson, Elaine; Guo, Ying; Cepurna, William O.; Morrison, John.

In: Experimental Eye Research, Vol. 88, No. 4, 30.04.2009, p. 808-815.

Research output: Contribution to journalArticle

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