Neurotoxic fragrance produces ceroid and myelin disease

Peter S. Spencer; Arnold B. Sterman; Dikran S. Horoupian; Marion M. Foulds

doi:10.1126/science.432669

Neurotoxic fragrance produces ceroid and myelin disease

Peter S. Spencer, Arnold B. Sterman, Dikran S. Horoupian, Marion M. Foulds

Neurology

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.

Original language	English (US)
Pages (from-to)	633-635
Number of pages	3
Journal	Science
Volume	204
Issue number	4393
DOIs	https://doi.org/10.1126/science.432669
State	Published - Jan 1 1979

Fingerprint

ASJC Scopus subject areas

General

Cite this

Spencer, P. S., Sterman, A. B., Horoupian, D. S., & Foulds, M. M. (1979). Neurotoxic fragrance produces ceroid and myelin disease. Science, 204(4393), 633-635. https://doi.org/10.1126/science.432669

@article{a5d0fb4ac3c649ba9887db9308fa4c36,

title = "Neurotoxic fragrance produces ceroid and myelin disease",

abstract = "Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.",

author = "Spencer, {Peter S.} and Sterman, {Arnold B.} and Horoupian, {Dikran S.} and Foulds, {Marion M.}",

year = "1979",

month = jan

day = "1",

doi = "10.1126/science.432669",

language = "English (US)",

volume = "204",

pages = "633--635",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4393",

}

TY - JOUR

T1 - Neurotoxic fragrance produces ceroid and myelin disease

AU - Spencer, Peter S.

AU - Sterman, Arnold B.

AU - Horoupian, Dikran S.

AU - Foulds, Marion M.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.

AB - Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.

UR - http://www.scopus.com/inward/record.url?scp=0018389979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018389979&partnerID=8YFLogxK

U2 - 10.1126/science.432669

DO - 10.1126/science.432669

M3 - Article

C2 - 432669

AN - SCOPUS:0018389979

VL - 204

SP - 633

EP - 635

JO - Science

JF - Science

SN - 0036-8075

IS - 4393

ER -

Access to Document

10.1126/science.432669