TY - JOUR
T1 - Neurotoxic fragrance produces ceroid and myelin disease
AU - Spencer, Peter S.
AU - Sterman, Arnold B.
AU - Horoupian, Dikran S.
AU - Foulds, Marion M.
PY - 1979
Y1 - 1979
N2 - Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.
AB - Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.
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U2 - 10.1126/science.432669
DO - 10.1126/science.432669
M3 - Article
C2 - 432669
AN - SCOPUS:0018389979
VL - 204
SP - 633
EP - 635
JO - Science
JF - Science
SN - 0036-8075
IS - 4393
ER -