Neurotoxic fragrance produces ceroid and myelin disease

Peter Spencer, Arnold B. Sterman, Dikran S. Horoupian, Marion M. Foulds

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.

Original languageEnglish (US)
Pages (from-to)633-635
Number of pages3
JournalScience
Volume204
Issue number4393
StatePublished - 1979
Externally publishedYes

Fingerprint

Ceroid
Myelin Sheath
Deodorants
Spinal Nerves
Soaps
Peripheral Nerves
Cosmetics
Spinal Cord
Industry
Extremities
Brain
versalide

ASJC Scopus subject areas

  • General

Cite this

Spencer, P., Sterman, A. B., Horoupian, D. S., & Foulds, M. M. (1979). Neurotoxic fragrance produces ceroid and myelin disease. Science, 204(4393), 633-635.

Neurotoxic fragrance produces ceroid and myelin disease. / Spencer, Peter; Sterman, Arnold B.; Horoupian, Dikran S.; Foulds, Marion M.

In: Science, Vol. 204, No. 4393, 1979, p. 633-635.

Research output: Contribution to journalArticle

Spencer, P, Sterman, AB, Horoupian, DS & Foulds, MM 1979, 'Neurotoxic fragrance produces ceroid and myelin disease', Science, vol. 204, no. 4393, pp. 633-635.
Spencer P, Sterman AB, Horoupian DS, Foulds MM. Neurotoxic fragrance produces ceroid and myelin disease. Science. 1979;204(4393):633-635.
Spencer, Peter ; Sterman, Arnold B. ; Horoupian, Dikran S. ; Foulds, Marion M. / Neurotoxic fragrance produces ceroid and myelin disease. In: Science. 1979 ; Vol. 204, No. 4393. pp. 633-635.
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