Neurotoxic fragrance produces ceroid and myelin disease

Peter S. Spencer; Arnold B. Sterman; Dikran S. Horoupian; Marion M. Foulds

doi:10.1126/science.432669

Neurotoxic fragrance produces ceroid and myelin disease

Peter S. Spencer, Arnold B. Sterman, Dikran S. Horoupian, Marion M. Foulds

Neurology

Research output: Contribution to journal › Article

35 Scopus citations

Abstract

Acetyl ethyl tetramethyl tetralin (AETT), a component of soaps, deodorants, and cosmetics, produces hyperirritability and limb weakness in rats repeatedly exposed to the compound. Brain, spinal cord, and peripheral nerves are discolored blue, show progressive neuronal ceroid degeneration, and develop spectacular myelin bubbling. These neurotoxic properties of AETT provide the basis for industry's decision to withdraw the compound from consumer products. In addition, AETT offers the experimentalist a new probe to explore the etiology and pathogeneses of human ceroid and myelin diseases.

Original language	English (US)
Pages (from-to)	633-635
Number of pages	3
Journal	Science
Volume	204
Issue number	4393
DOIs	https://doi.org/10.1126/science.432669
State	Published - Jan 1 1979

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Spencer, P. S., Sterman, A. B., Horoupian, D. S., & Foulds, M. M. (1979). Neurotoxic fragrance produces ceroid and myelin disease. Science, 204(4393), 633-635. https://doi.org/10.1126/science.432669

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