Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies

Bruce G. Gold, Esther Udina, Dennis Bourdette, Xavier Navarro

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

FK506 (tacrolimus, Prograf®) is an immunosuppressant drug that also has profound neuroregenerative and neuroprotective actions independent of its immunosuppressant activity. The separation of these properties has led to the development of non-immunosuppressant derivatives that retain the neurotrophic activity. This review focuses on the peripheral nerve actions of these compounds following mechanical injury (nerve crush or transection with graft repair) and in models of inflammatory neuropathies. Whereas FK506 may be indicative for the treatment of inflammatory neuropathies where its immunosuppressive action would be advantageous, non-immunosuppressant derivatives represent a new class of potential therapeutic agents for the treatment of human neurological conditions in general. Moreover, these studies have led to the discovery of a novel mechanism whereby these compounds activate intrinsic neuroregenerative and neuroprotective pathways in the neuron.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalNeurological Research
Volume26
Issue number4
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Tacrolimus
Immunosuppressive Agents
Nerve Crush
Peripheral Nerves
Transplants
Neurons
Wounds and Injuries
Pharmaceutical Preparations
Therapeutics

Keywords

  • FK506
  • FKBP
  • Immunosuppressant
  • Inflammatory
  • Nerve regeneration
  • Neuroprotection
  • Sciatic nerve

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies. / Gold, Bruce G.; Udina, Esther; Bourdette, Dennis; Navarro, Xavier.

In: Neurological Research, Vol. 26, No. 4, 06.2004, p. 371-380.

Research output: Contribution to journalArticle

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