Neuropsychological predictors of BOLD response during a spatial working memory task in adolescents: What can performance tell us about fMRI response patterns?

Bonnie J. Nagel, Valerie C. Barlett, Alecia D. Schweinsburg, Susan F. Tapert

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The relationship between standardized neuropsychological test performance and functional magnetic resonance imaging (fMRI) response during cognitive tasks is largely unknown. This exploratory investigation examined the relationship between neuropsychological test performance and fMRI response to a spatial working memory (SWM) task among 49 typically developing adolescents. Participants were administered a variety of neuropsychological tests in the domains of working memory, visuospatial skills, executive functioning, attention, learning and memory, visuomotor skills and processing speed, and language functioning. Neuropsychological domain scores were used to predict fMRI response during a SWM task. Results suggest that in many brain regions, neuropsychological performance negatively predicts fMRI response, suggesting that those teens with better neuropsychological abilities required fewer neural resources to adequately perform the task. This study provides further understanding of how neuropsychological abilities relate to neural activity during fMRI tasks, and provides an important link between neuropsychological and fMRI research.

Original languageEnglish (US)
Pages (from-to)823-839
Number of pages17
JournalJournal of Clinical and Experimental Neuropsychology
Volume27
Issue number7
DOIs
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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