Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

Vemuganti L. Raghavendra Rao, Aclan Dogan, Kathryn G. Todd, Kellie K. Bowen, Robert J. Dempsey

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalBrain Research
Volume911
Issue number1
DOIs
StatePublished - Aug 17 2001
Externally publishedYes

Fingerprint

Memantine
N-Methyl-D-Aspartate Receptors
Hippocampal CA2 Region
Hippocampal CA3 Region
Wounds and Injuries
Equipment and Supplies
Neuroprotection
Traumatic Brain Injury

Keywords

  • Excitotoxicity
  • Glutamate antagonist
  • Memantine
  • Neuroprotection
  • Secondary neuronal death
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats. / Raghavendra Rao, Vemuganti L.; Dogan, Aclan; Todd, Kathryn G.; Bowen, Kellie K.; Dempsey, Robert J.

In: Brain Research, Vol. 911, No. 1, 17.08.2001, p. 96-100.

Research output: Contribution to journalArticle

Raghavendra Rao, Vemuganti L. ; Dogan, Aclan ; Todd, Kathryn G. ; Bowen, Kellie K. ; Dempsey, Robert J. / Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats. In: Brain Research. 2001 ; Vol. 911, No. 1. pp. 96-100.
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