Neuropathology in the adult changes in thought study: A review

Joshua A. Sonnen, Eric B. Larson, Sebastien Haneuse, Randy Woltjer, Ge Li, Paul K. Crane, Suzanne Craft, Thomas J. Montine

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer's and Lewy body pathology are well appreciated. Recent studies with brain autopsies have highlighted the high prevalence of vascular disease as an independent, but often co-morbid contributor to dementia. The Adult Changes in Thought Study is a community-based, longitudinal study of brain aging and cognitive decline which has recently confirmed cerebral microinfarcts as a strong correlate of cognitive impairment and dementia. This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease.

Original languageEnglish (US)
Pages (from-to)703-711
Number of pages9
JournalJournal of Alzheimer's Disease
Volume18
Issue number3
DOIs
StatePublished - 2009

Keywords

  • Aging
  • Community-based
  • Longitudinal
  • Microinfarct
  • Neuropathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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