Neuropathology associated with stillbirth

Marjorie Grafe, Hannah C. Kinney

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Neuropathologic findings in stillbirths oftentimes provide insight into the specific mechanisms leading to death. Examination of the brains of stillborn infants may also identify pathophysiologic processes that result in prenatal brain injury in liveborn as well as stillborn infants and that lead to neurologic disorders in liveborn infants, such as cerebral palsy or the sudden infant death syndrome (SIDS). A variety of abnormalities are found in the brains of stillborns, the most common including cerebral white matter necrosis (periventricular leukomalacia) or gliosis, germinal matrix or intraventricular hemorrhage, cerebral infarcts, pontosubicular necrosis, and spinal cord or brainstem necrosis. The 2 major hypotheses that have been proposed for the pathophysiology of cerebral white matter injury in the perinatal period are hypoxia/ischemia and infection/cytokines as the basis for injury. The fetal brain may be selectively vulnerable to various insults at specific stages of development.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalSeminars in Perinatology
Volume26
Issue number1
StatePublished - 2002
Externally publishedYes

Fingerprint

Stillbirth
Necrosis
Prenatal Injuries
Brain
Periventricular Leukomalacia
Gliosis
Sudden Infant Death
Cerebral Hemorrhage
Wounds and Injuries
Cerebral Palsy
Nervous System Diseases
Brain Injuries
Brain Stem
Spinal Cord
Ischemia
Cytokines
Infection
Neuropathology
White Matter

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Neuropathology associated with stillbirth. / Grafe, Marjorie; Kinney, Hannah C.

In: Seminars in Perinatology, Vol. 26, No. 1, 2002, p. 83-88.

Research output: Contribution to journalArticle

Grafe, M & Kinney, HC 2002, 'Neuropathology associated with stillbirth', Seminars in Perinatology, vol. 26, no. 1, pp. 83-88.
Grafe, Marjorie ; Kinney, Hannah C. / Neuropathology associated with stillbirth. In: Seminars in Perinatology. 2002 ; Vol. 26, No. 1. pp. 83-88.
@article{dc00ca7c68224b999dba71e51d5e96bf,
title = "Neuropathology associated with stillbirth",
abstract = "Neuropathologic findings in stillbirths oftentimes provide insight into the specific mechanisms leading to death. Examination of the brains of stillborn infants may also identify pathophysiologic processes that result in prenatal brain injury in liveborn as well as stillborn infants and that lead to neurologic disorders in liveborn infants, such as cerebral palsy or the sudden infant death syndrome (SIDS). A variety of abnormalities are found in the brains of stillborns, the most common including cerebral white matter necrosis (periventricular leukomalacia) or gliosis, germinal matrix or intraventricular hemorrhage, cerebral infarcts, pontosubicular necrosis, and spinal cord or brainstem necrosis. The 2 major hypotheses that have been proposed for the pathophysiology of cerebral white matter injury in the perinatal period are hypoxia/ischemia and infection/cytokines as the basis for injury. The fetal brain may be selectively vulnerable to various insults at specific stages of development.",
author = "Marjorie Grafe and Kinney, {Hannah C.}",
year = "2002",
language = "English (US)",
volume = "26",
pages = "83--88",
journal = "Seminars in Perinatology",
issn = "0146-0005",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Neuropathology associated with stillbirth

AU - Grafe, Marjorie

AU - Kinney, Hannah C.

PY - 2002

Y1 - 2002

N2 - Neuropathologic findings in stillbirths oftentimes provide insight into the specific mechanisms leading to death. Examination of the brains of stillborn infants may also identify pathophysiologic processes that result in prenatal brain injury in liveborn as well as stillborn infants and that lead to neurologic disorders in liveborn infants, such as cerebral palsy or the sudden infant death syndrome (SIDS). A variety of abnormalities are found in the brains of stillborns, the most common including cerebral white matter necrosis (periventricular leukomalacia) or gliosis, germinal matrix or intraventricular hemorrhage, cerebral infarcts, pontosubicular necrosis, and spinal cord or brainstem necrosis. The 2 major hypotheses that have been proposed for the pathophysiology of cerebral white matter injury in the perinatal period are hypoxia/ischemia and infection/cytokines as the basis for injury. The fetal brain may be selectively vulnerable to various insults at specific stages of development.

AB - Neuropathologic findings in stillbirths oftentimes provide insight into the specific mechanisms leading to death. Examination of the brains of stillborn infants may also identify pathophysiologic processes that result in prenatal brain injury in liveborn as well as stillborn infants and that lead to neurologic disorders in liveborn infants, such as cerebral palsy or the sudden infant death syndrome (SIDS). A variety of abnormalities are found in the brains of stillborns, the most common including cerebral white matter necrosis (periventricular leukomalacia) or gliosis, germinal matrix or intraventricular hemorrhage, cerebral infarcts, pontosubicular necrosis, and spinal cord or brainstem necrosis. The 2 major hypotheses that have been proposed for the pathophysiology of cerebral white matter injury in the perinatal period are hypoxia/ischemia and infection/cytokines as the basis for injury. The fetal brain may be selectively vulnerable to various insults at specific stages of development.

UR - http://www.scopus.com/inward/record.url?scp=0036179787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036179787&partnerID=8YFLogxK

M3 - Article

C2 - 11876572

AN - SCOPUS:0036179787

VL - 26

SP - 83

EP - 88

JO - Seminars in Perinatology

JF - Seminars in Perinatology

SN - 0146-0005

IS - 1

ER -