Neurons in the frontal cortex of the rat carry multiple opiate receptors

John Williams, W. Zieglgänsberger

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Acute desensitization to the inhibitory action of iontophoretically applied opiate alkaloids and opioid peptides was used to investigate the possibility of multiple opiate receptors located on single neurons in the frontal cortex of rats. Such short term exposure resulted in adaptive processes which were similar to tolerance to and dependence on opiate agonists occurring after chronic treatment. Neurons desensitized to methionine-enkephalin (ME) or D-Ala2, D-Leu5-enkephalin (DADL) became subsensitive to morphine, whereas cells desensitized to morphine remain sensitive to the inhibitory action of the opioid peptides. This lack of cross-desensitization may suggest the existence of multiple opiate receptors on the same cell.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalBrain Research
Volume226
Issue number1-2
DOIs
StatePublished - Dec 7 1981
Externally publishedYes

Fingerprint

Opioid Peptides
Opioid Receptors
Frontal Lobe
Neurons
Morphine
Opiate Alkaloids
Opioid-Related Disorders
Methionine Enkephalin
Psychologic Desensitization

Keywords

  • acute desensitization
  • frontal cortex
  • multiple opiate receptors
  • single units

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neurons in the frontal cortex of the rat carry multiple opiate receptors. / Williams, John; Zieglgänsberger, W.

In: Brain Research, Vol. 226, No. 1-2, 07.12.1981, p. 304-308.

Research output: Contribution to journalArticle

Williams, John ; Zieglgänsberger, W. / Neurons in the frontal cortex of the rat carry multiple opiate receptors. In: Brain Research. 1981 ; Vol. 226, No. 1-2. pp. 304-308.
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