Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

Gabriella D'Arcangelo, Kenneth Paradiso, Dawn Shepherd, Paul Brehm, Simon Halegoua, Gail Mandel

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Neuronal growth factors regulate the expression of voltage-activated sodium current in differentiating sympathetic neurons and PC12 cells. We show that, in PC12 cells, the NGF- and FGF-induced sodium current results from increased expression of two distinct sodium channel types. Sodium current results from the rapid induction of a novel sodium channel transcript, also found in peripheral neurons, and from the long term induction of brain type II/IIA mRNA. Expression of the type II/IIA sodium channel requires activation of the cyclic AMP-dependent protein kinase (A-kinase), whereas induction of the peripheral neuron type sodium channel occurs through an A-kinase-independent signal transduction pathway. These findings suggest that the two sodium channel types act in concert to ensure the generation of action potentials during neuronal differentiation.

Original languageEnglish (US)
Pages (from-to)915-921
Number of pages7
JournalJournal of Cell Biology
Volume122
Issue number4
StatePublished - Aug 1993
Externally publishedYes

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Sodium Channels
Signal Transduction
Intercellular Signaling Peptides and Proteins
Sodium
PC12 Cells
Neurons
Nerve Growth Factor
Adenosine Monophosphate
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Action Potentials
Messenger RNA
Brain

ASJC Scopus subject areas

  • Cell Biology

Cite this

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. / D'Arcangelo, Gabriella; Paradiso, Kenneth; Shepherd, Dawn; Brehm, Paul; Halegoua, Simon; Mandel, Gail.

In: Journal of Cell Biology, Vol. 122, No. 4, 08.1993, p. 915-921.

Research output: Contribution to journalArticle

D'Arcangelo, Gabriella ; Paradiso, Kenneth ; Shepherd, Dawn ; Brehm, Paul ; Halegoua, Simon ; Mandel, Gail. / Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. In: Journal of Cell Biology. 1993 ; Vol. 122, No. 4. pp. 915-921.
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