Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann, Fredrick J. Seil, Peter Spencer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalJournal of Physiology Paris
Volume92
Issue number3-4
DOIs
StatePublished - Jun 1998

Fingerprint

Pyridostigmine Bromide
Spinal Cord
Muscles
Nerve Fibers
Pharmaceutical Preparations
Cholinergic Agents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture. / Drake-Baumann, Rosemarie; Seil, Fredrick J.; Spencer, Peter.

In: Journal of Physiology Paris, Vol. 92, No. 3-4, 06.1998, p. 305-308.

Research output: Contribution to journalArticle

Drake-Baumann, Rosemarie ; Seil, Fredrick J. ; Spencer, Peter. / Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture. In: Journal of Physiology Paris. 1998 ; Vol. 92, No. 3-4. pp. 305-308.
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