Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann, Fredrick J. Seil, Peter S. Spencer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalJournal of Physiology Paris
Volume92
Issue number3-4
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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