Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann; Fredrick J. Seil; Peter S. Spencer

doi:10.1016/S0928-4257(98)80038-7

Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

Rosemarie Drake-Baumann, Fredrick J. Seil, Peter S. Spencer

Neurology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.

Original language	English (US)
Pages (from-to)	305-308
Number of pages	4
Journal	Journal of Physiology Paris
Volume	92
Issue number	3-4
DOIs	https://doi.org/10.1016/S0928-4257(98)80038-7
State	Published - Jan 1 1998

ASJC Scopus subject areas

Neuroscience(all)
Physiology (medical)

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10.1016/S0928-4257(98)80038-7

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abstract = "Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.",

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