Neurologic diseases associated with use of plant components with toxic potential

Peter Spencer, A. C. Ludolph, G. E. Kisby

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Epidemics of neurotoxic disease in developing regions of the world are often associated with dietary dependence on plant components with inherent toxic potential or which have spoiled and become contaminated with mycotoxins. Diseases triggered by plant toxins include lathyrism and cassavism, types of irreversible spastic parapareses associated with staple diets of grass pea and bitter cassava root, respectively. Mildewed sugarcane poisoning, an encephalopathy and tardive dystonia, illustrates the neurotoxic effects of a widely distributed plant and fungal toxin. Food and medicinal use of the neurotoxic cycad plant is thought to have a role in the etiology of western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia. Plant-associated neurotoxicity is a significant and preventable cause of morbidity in certain regions of Africa, Asia, and Oceania.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalEnvironmental Research
Volume62
Issue number1
DOIs
StatePublished - 1993

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Plant Structures
Mycotoxins
Poisons
Nervous System Diseases
Lathyrism
Nutrition
Oceania
toxin
Plant Diseases
Saccharum
Manihot
Muscle Spasticity
Peas
Amyotrophic Lateral Sclerosis
Parkinsonian Disorders
Brain Diseases
Poaceae
Poisoning
cassava
Dementia

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Neurologic diseases associated with use of plant components with toxic potential. / Spencer, Peter; Ludolph, A. C.; Kisby, G. E.

In: Environmental Research, Vol. 62, No. 1, 1993, p. 106-113.

Research output: Contribution to journalArticle

Spencer, Peter ; Ludolph, A. C. ; Kisby, G. E. / Neurologic diseases associated with use of plant components with toxic potential. In: Environmental Research. 1993 ; Vol. 62, No. 1. pp. 106-113.
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