Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

Eric Schnell, Thomas H. Long, AeSoon L. Bensen, Eric K. Washburn, Gary Westbrook

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.

Original languageEnglish (US)
Article number71
JournalFrontiers in Neuroscience
Issue number8 APR
DOIs
StatePublished - 2014

Fingerprint

Neurons
Dendrites
Cell Survival
Spine
Growth
Proteins
neuroligin 1

Keywords

  • Adult neurogenesis
  • Cell survival
  • Dendritic growth
  • Dendritic spine
  • Neuroligin-1
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons. / Schnell, Eric; Long, Thomas H.; Bensen, AeSoon L.; Washburn, Eric K.; Westbrook, Gary.

In: Frontiers in Neuroscience, No. 8 APR, 71, 2014.

Research output: Contribution to journalArticle

@article{df41a8c6bd044e75a2f8bde3e82003e6,
title = "Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons",
abstract = "Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.",
keywords = "Adult neurogenesis, Cell survival, Dendritic growth, Dendritic spine, Neuroligin-1, Synaptogenesis",
author = "Eric Schnell and Long, {Thomas H.} and Bensen, {AeSoon L.} and Washburn, {Eric K.} and Gary Westbrook",
year = "2014",
doi = "10.3389/fnins.2014.00071",
language = "English (US)",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "8 APR",

}

TY - JOUR

T1 - Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

AU - Schnell, Eric

AU - Long, Thomas H.

AU - Bensen, AeSoon L.

AU - Washburn, Eric K.

AU - Westbrook, Gary

PY - 2014

Y1 - 2014

N2 - Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.

AB - Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.

KW - Adult neurogenesis

KW - Cell survival

KW - Dendritic growth

KW - Dendritic spine

KW - Neuroligin-1

KW - Synaptogenesis

UR - http://www.scopus.com/inward/record.url?scp=84904898587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904898587&partnerID=8YFLogxK

U2 - 10.3389/fnins.2014.00071

DO - 10.3389/fnins.2014.00071

M3 - Article

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - 8 APR

M1 - 71

ER -