Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

Eric Schnell, Thomas H. Long, Ae Soon L. Bensen, Eric K. Washburn, Gary L. Westbrook

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.

Original languageEnglish (US)
Article number71
JournalFrontiers in Neuroscience
Issue number8 APR
DOIs
StatePublished - 2014

Keywords

  • Adult neurogenesis
  • Cell survival
  • Dendritic growth
  • Dendritic spine
  • Neuroligin-1
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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