Neuroleptic-induced parkinsonism in older schizophrenics

William F. Hoffman, Sharon M. Labs, Daniel E. Casey

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


The association of neuroleptic drug-induced parkinsonism (DIP) with factors related to brain structure and function are poorly understood. Twenty-one medicated schizophrenics over age 55 years were evaluated for parkinsonism, tardive dyskinesia, psychiatric symptoms, ventricular/brain ratio (VBR), and neuropsychological function. Sixteen (76%) of the patients had DIP, whereas 10 (48%) had tardive dyskinesia. Increased severity of parkinsonism was significantly associated with larger VBR and the severity of negative symptoms. Severity of parkinsonism predicted poor visual-spatial function, whereas negative symptoms were modestly predictive of impairment in both verbal ability and cognitive flexibility. These findings suggest that brain atrophy may be a risk factor for DIP. The pattern of cognitive dysfunction associated with DIP in this sample is similar to that found in idiopathic Parkinson's disease. Dopaminergic dysfunction may underlie the pattern of pathology described in this report.

Original languageEnglish (US)
Pages (from-to)427-439
Number of pages13
JournalBiological Psychiatry
Issue number4
StatePublished - Apr 1987

ASJC Scopus subject areas

  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Neuroleptic-induced parkinsonism in older schizophrenics'. Together they form a unique fingerprint.

Cite this