Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation

Jennifer M. Loftis; Jonathan Taylor; Rebekah Hudson; Evan J. Firsick

doi:10.1016/j.jneuroim.2019.577006

Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation

Jennifer M. Loftis, Jonathan Taylor, Rebekah Hudson, Evan J. Firsick

Psychiatry

Research output: Contribution to journal › Article › peer-review

Abstract

Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.

Original language	English (US)
Article number	577006
Journal	Journal of Neuroimmunology
Volume	335
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577006
State	Published - Oct 15 2019

Keywords

Alcohol use disorder
Blood brain barrier
Cognition
Gila
Inflammation
Lymphocytic choriomeningitis virus clone 13

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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title = "Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation",

abstract = "Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.",

keywords = "Alcohol use disorder, Blood brain barrier, Cognition, Gila, Inflammation, Lymphocytic choriomeningitis virus clone 13",

author = "Loftis, {Jennifer M.} and Jonathan Taylor and Rebekah Hudson and Firsick, {Evan J.}",

note = "Funding Information: This work was supported by the U.S. Department of Veterans Affairs Biomedical Laboratory Research and Development Merit Review grant (grant number: I01 BX002061 ) (JML) and the National Institute on Drug Abuse (grant number: DA P50DA018165 ) (JML). The work was conducted using facilities at Veterans Affairs Portland Health Care System (Portland, OR; USA). RH, JT, and EJF were employed as Research Assistants and JML as a Research Scientist at the Veterans Affairs Portland Health Care System, Portland, Oregon. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.",

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