Abstract
Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.
| Original language | English (US) |
|---|---|
| Article number | 577006 |
| Journal | Journal of Neuroimmunology |
| Volume | 335 |
| DOIs | |
| State | Published - Oct 15 2019 |
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Keywords
- Alcohol use disorder
- Blood brain barrier
- Cognition
- Gila
- Inflammation
- Lymphocytic choriomeningitis virus clone 13
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
Cite this
Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection : An initial investigation. / Loftis, Jennifer; Taylor, Jonathan; Hudson, Rebekah; Firsick, Evan J.
In: Journal of Neuroimmunology, Vol. 335, 577006, 15.10.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection
T2 - An initial investigation
AU - Loftis, Jennifer
AU - Taylor, Jonathan
AU - Hudson, Rebekah
AU - Firsick, Evan J.
PY - 2019/10/15
Y1 - 2019/10/15
N2 - Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.
AB - Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.
KW - Alcohol use disorder
KW - Blood brain barrier
KW - Cognition
KW - Gila
KW - Inflammation
KW - Lymphocytic choriomeningitis virus clone 13
UR - http://www.scopus.com/inward/record.url?scp=85068982563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068982563&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2019.577006
DO - 10.1016/j.jneuroim.2019.577006
M3 - Article
AN - SCOPUS:85068982563
VL - 335
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 577006
ER -