Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation

Jennifer Loftis, Jonathan Taylor, Rebekah Hudson, Evan J. Firsick

Research output: Contribution to journalArticle

Abstract

Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.

Original languageEnglish (US)
Article number577006
JournalJournal of Neuroimmunology
Volume335
DOIs
StatePublished - Oct 15 2019

Fingerprint

Virus Diseases
Alcoholism
Alcohols
Lymphocytic choriomeningitis virus
Brain
Cognition
Central Nervous System
Clone Cells
Cognitive Dysfunction
Viruses
Inflammation

Keywords

  • Alcohol use disorder
  • Blood brain barrier
  • Cognition
  • Gila
  • Inflammation
  • Lymphocytic choriomeningitis virus clone 13

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection : An initial investigation. / Loftis, Jennifer; Taylor, Jonathan; Hudson, Rebekah; Firsick, Evan J.

In: Journal of Neuroimmunology, Vol. 335, 577006, 15.10.2019.

Research output: Contribution to journalArticle

@article{66c21b639f594674b41e37f9f2ae1b01,
title = "Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation",
abstract = "Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.",
keywords = "Alcohol use disorder, Blood brain barrier, Cognition, Gila, Inflammation, Lymphocytic choriomeningitis virus clone 13",
author = "Jennifer Loftis and Jonathan Taylor and Rebekah Hudson and Firsick, {Evan J.}",
year = "2019",
month = "10",
day = "15",
doi = "10.1016/j.jneuroim.2019.577006",
language = "English (US)",
volume = "335",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

TY - JOUR

T1 - Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection

T2 - An initial investigation

AU - Loftis, Jennifer

AU - Taylor, Jonathan

AU - Hudson, Rebekah

AU - Firsick, Evan J.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.

AB - Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (LCMV) clone 13. LCMV-infected mice exposed to alcohol had increased peripheral inflammation and impaired cognitive function (as indicated by performance on the novel object recognition test). Initial findings suggest that brain region-specific dysregulation of microglial response to viral infection may contribute to cognitive impairments in the context of heavy alcohol use.

KW - Alcohol use disorder

KW - Blood brain barrier

KW - Cognition

KW - Gila

KW - Inflammation

KW - Lymphocytic choriomeningitis virus clone 13

UR - http://www.scopus.com/inward/record.url?scp=85068982563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068982563&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2019.577006

DO - 10.1016/j.jneuroim.2019.577006

M3 - Article

AN - SCOPUS:85068982563

VL - 335

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577006

ER -