Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

A. Lerner, A. Bagic, Eilis Boudreau, T. Hanakawa, F. Pagan, Z. Mari, W. Bara-Jimenez, M. Aksu, G. Garraux, J. M. Simmons, S. Sato, D. L. Murphy, M. Hallett

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. METHODS: We used [O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.

Original languageEnglish (US)
Pages (from-to)1979-1987
Number of pages9
JournalNeurology
Volume68
Issue number23
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Tics
Tourette Syndrome
Neuroimaging
Sleep Stages
Cerebellum
Putamen
Motor Cortex
Thalamus
Sleep
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

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Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome. / Lerner, A.; Bagic, A.; Boudreau, Eilis; Hanakawa, T.; Pagan, F.; Mari, Z.; Bara-Jimenez, W.; Aksu, M.; Garraux, G.; Simmons, J. M.; Sato, S.; Murphy, D. L.; Hallett, M.

In: Neurology, Vol. 68, No. 23, 06.2007, p. 1979-1987.

Research output: Contribution to journalArticle

Lerner, A, Bagic, A, Boudreau, E, Hanakawa, T, Pagan, F, Mari, Z, Bara-Jimenez, W, Aksu, M, Garraux, G, Simmons, JM, Sato, S, Murphy, DL & Hallett, M 2007, 'Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome', Neurology, vol. 68, no. 23, pp. 1979-1987. https://doi.org/10.1212/01.wnl.0000264417.18604.12
Lerner, A. ; Bagic, A. ; Boudreau, Eilis ; Hanakawa, T. ; Pagan, F. ; Mari, Z. ; Bara-Jimenez, W. ; Aksu, M. ; Garraux, G. ; Simmons, J. M. ; Sato, S. ; Murphy, D. L. ; Hallett, M. / Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome. In: Neurology. 2007 ; Vol. 68, No. 23. pp. 1979-1987.
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AU - Bagic, A.

AU - Boudreau, Eilis

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AU - Pagan, F.

AU - Mari, Z.

AU - Bara-Jimenez, W.

AU - Aksu, M.

AU - Garraux, G.

AU - Simmons, J. M.

AU - Sato, S.

AU - Murphy, D. L.

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