Neurohypophyseal and pituitary-adrenocortical responses to the alpha1 agonist methoxamine in humans

Allen Radani, Elaine R. Peskind, Charles W. Wilkinson, Richard C. Veith, Daniel Dorsa, Rosemary D. Leake, M. Gore Ervin, Murray A. Raskind

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To test the hypothesis that the release of neurohypophyseal peptides into plasma in humans is stimulated by a central nervous system (CNS) alphai adrenergic mechanism, we measured the responses of arginine vasopressin (AVP) and oxytocin (OT) to intravenous methoxamine, an alpha1 agonist which enters the CNS following peripheral administration. The potential confound of baroreceptor inhibition of AVP release by the pressor effect of methoxamine was addressed by measuring the plasma AVP response to infusion of norepinephrine (NE), an alphai agonist which does not enter the CNS and which produced an equivalent pressor effect. We also assessed the pituitary adrenocortical system responses to methoxamine and norepinephrine infusions by measuring plasma ACTH and cortisol concentrations. In addition, plasma NE and epinephrine were measured. Methoxamine, but not NE, increased plasma AVP compared to placebo infusion. Neither methoxamine nor NE affected plasma OT. The AVP elevation was delayed until more than 60 min after the methoxamine infusion began and the peak AVP level occurred 30 min after cessation of the infusion. In contrast, ACTH and cortisol increased early during methoxamine infusion and ACTH returned to baseline promptly after the infusion ceased. Although it is possible that the AVP response to methoxamine reflected stimulation of AVP release at a CNS level, it is also possible that the AVP increase represented a rebound response to withdrawal of methoxamine.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalNeuroendocrinology
Volume55
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Methoxamine
Arginine Vasopressin
Norepinephrine
Central Nervous System
Adrenocorticotropic Hormone
Hydrocortisone
Posterior Pituitary Hormones
Vasotocin
Pressoreceptors
Oxytocin
Adrenergic Agents
Epinephrine
Placebos

Keywords

  • ACTH
  • Cortisol
  • Methoxamine
  • Vasopressin
  • α<inf>1</inf>-adrenergic receptors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Radani, A., Peskind, E. R., Wilkinson, C. W., Veith, R. C., Dorsa, D., Leake, R. D., ... Raskind, M. A. (1992). Neurohypophyseal and pituitary-adrenocortical responses to the alpha1 agonist methoxamine in humans. Neuroendocrinology, 55(4), 361-366. https://doi.org/10.1159/000126145

Neurohypophyseal and pituitary-adrenocortical responses to the alpha1 agonist methoxamine in humans. / Radani, Allen; Peskind, Elaine R.; Wilkinson, Charles W.; Veith, Richard C.; Dorsa, Daniel; Leake, Rosemary D.; Ervin, M. Gore; Raskind, Murray A.

In: Neuroendocrinology, Vol. 55, No. 4, 1992, p. 361-366.

Research output: Contribution to journalArticle

Radani, A, Peskind, ER, Wilkinson, CW, Veith, RC, Dorsa, D, Leake, RD, Ervin, MG & Raskind, MA 1992, 'Neurohypophyseal and pituitary-adrenocortical responses to the alpha1 agonist methoxamine in humans', Neuroendocrinology, vol. 55, no. 4, pp. 361-366. https://doi.org/10.1159/000126145
Radani, Allen ; Peskind, Elaine R. ; Wilkinson, Charles W. ; Veith, Richard C. ; Dorsa, Daniel ; Leake, Rosemary D. ; Ervin, M. Gore ; Raskind, Murray A. / Neurohypophyseal and pituitary-adrenocortical responses to the alpha1 agonist methoxamine in humans. In: Neuroendocrinology. 1992 ; Vol. 55, No. 4. pp. 361-366.
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