Neurogenetic studies of alcohol addiction

John C. Crabbe

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Neurogenetic studies of alcohol dependence have relied substantially on genetic animal models, particularly rodents. Studies of inbred strains, selectively bred lines and mutants bearing genes whose function has been targeted for over or under expression are reviewed. Studies focused on gene expression changes are the most recent contributors to this literature, and some genetic effects may work through epigenetic mechanisms. In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex.

Original languageEnglish (US)
Pages (from-to)3201-3211
Number of pages11
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1507
StatePublished - Oct 12 2008
Externally publishedYes


  • Alcohol
  • Candidate genes
  • Genetic animal models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Neurogenetic studies of alcohol addiction'. Together they form a unique fingerprint.

Cite this