Neurogenetic studies of alcohol addiction

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Neurogenetic studies of alcohol dependence have relied substantially on genetic animal models, particularly rodents. Studies of inbred strains, selectively bred lines and mutants bearing genes whose function has been targeted for over or under expression are reviewed. Studies focused on gene expression changes are the most recent contributors to this literature, and some genetic effects may work through epigenetic mechanisms. In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex.

Original languageEnglish (US)
Pages (from-to)3201-3211
Number of pages11
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1507
DOIs
StatePublished - Oct 12 2008

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Keywords

  • Alcohol
  • Candidate genes
  • Genetic animal models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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