Neurofibromatosis 1: Recognition and management of associated neuroblastoma

Susan Hayflick, K. J. Hofman, W. W. Tunnessen, B. G. Leventhal, D. L. Dudgeon

Research output: Contribution to journalArticle

11 Scopus citations


Neurofibroma and neuroblastoma both arise from the neural crest, and there has long been speculation regarding a pathogenetic relationship between them. Clinical characteristics do not necessarily distinguish these tumors, therefore the diagnosis of neuroblastoma should be considered in all children with neurofibromatosis 1 (NF-1) who have a rapidly growing or inaccessible mass. A careful physical examination, imaging studies, and urinary catecholamine measurement are indicated. In a child with NF-1 and malignancy, direct tissue examination may be necessary to differentiate malignant from nonmalignant tumor and guide therapy. Furthermore, with the significantly increased risk of certain types of childhood cancer in these patients, we recommend evaluation for this common heritable condition in all patients with malignancy.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalPediatric Dermatology
Issue number4
Publication statusPublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hayflick, S., Hofman, K. J., Tunnessen, W. W., Leventhal, B. G., & Dudgeon, D. L. (1990). Neurofibromatosis 1: Recognition and management of associated neuroblastoma. Pediatric Dermatology, 7(4), 293-295.