Neuroendocrinology of female reproduction: Review, models, and potential approaches for risk assessment

David Hess

    Research output: Contribution to journalArticle

    Abstract

    The central role of the mammalian hypothalamic-pituitary axis in regulating female reproductive cycles is reviewed. A variety of animal models and techniques that offer increased sensitivity, speed, and flexibility over traditional reproductive toxicologic approaches for short term testing or screening are discussed, including the pivotal analysis of gonadotrophin releasing hormone (GnRH) pulse generator activity in vivo and in vitro. Other neuroendocrine techniques that require further development, but provide potential approaches to demonstrate specific sites or mechanisms of action for toxic effects on the hypothalamic-pituitary axis are suggested.

    Original languageEnglish (US)
    Pages (from-to)139-145
    Number of pages7
    JournalReproductive Toxicology
    Volume1
    Issue number2
    DOIs
    StatePublished - 1987

    Fingerprint

    Neuroendocrinology
    Toxic Actions
    Pulse generators
    Gonadotropin-Releasing Hormone
    Risk assessment
    Reproduction
    Screening
    Animals
    Animal Models
    Testing
    In Vitro Techniques

    Keywords

    • Animal models
    • Female reproductive cycles
    • Gonadotrophins
    • Hypothalamus
    • Neuroendocrine
    • Pituitary
    • Pulse generator
    • Risk assessment

    ASJC Scopus subject areas

    • Toxicology

    Cite this

    Neuroendocrinology of female reproduction : Review, models, and potential approaches for risk assessment. / Hess, David.

    In: Reproductive Toxicology, Vol. 1, No. 2, 1987, p. 139-145.

    Research output: Contribution to journalArticle

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