Neuroendocrinology of female reproduction: Review, models, and potential approaches for risk assessment

David L. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

The central role of the mammalian hypothalamic-pituitary axis in regulating female reproductive cycles is reviewed. A variety of animal models and techniques that offer increased sensitivity, speed, and flexibility over traditional reproductive toxicologic approaches for short term testing or screening are discussed, including the pivotal analysis of gonadotrophin releasing hormone (GnRH) pulse generator activity in vivo and in vitro. Other neuroendocrine techniques that require further development, but provide potential approaches to demonstrate specific sites or mechanisms of action for toxic effects on the hypothalamic-pituitary axis are suggested.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalReproductive Toxicology
Volume1
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Animal models
  • Female reproductive cycles
  • Gonadotrophins
  • Hypothalamus
  • Neuroendocrine
  • Pituitary
  • Pulse generator
  • Risk assessment

ASJC Scopus subject areas

  • Toxicology

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