TY - CHAP
T1 - Neuroendocrine regulation of puberty
AU - Terasawa, Ei
AU - Ojeda, S. R.
N1 - Funding Information:
Sergio R. Ojeda, DVM, head, Neuroscience Division, was recruited to the ONPRC in 1987 with the charge of establishing a Division of Neuroscience at the center. Prior to joining the ONPRC, he was a professor of physiology at the University of Texas Southwestern Medical Center in Dallas, Texas. He is a well-recognized developmental neuroendocrinologist who has published over 340 peer-reviewed articles and chapters in this field. He is also the co-editor of a textbook of endocrine physiology, which is in its fifth edition, and is widely used by medical and graduate schools throughout the world. Dr. Ojeda has been invited to deliver more than 250 lectures, including State-of-the-Art, Plenary, Keynote, and Distinguished Scientist lectures, both nationally and abroad. He has served as an associate editor for the journals years. Currently, he is the PI of two NIH R01 grants and project leader of an NIH U54 Project grant. Endocrinology and Neuroendocrinology , and as an editorial board member for the journals American Journal of Physiology , Endocrinology , Neuroendocrinology , Journal of Neuroendocrinology , and Methods in Neuroscience . He is an elected honorary (corresponding) member of the European Society of Pediatric Endocrinology and the Chilean Society of Endocrinology and Metabolism. Dr. Ojeda has served as a regular member of the Biochemical Endocrinology NIH Study Section, and the NIH Population Research Committee. He also served on the NIH National Institute of Child Health Development Advisory Council and is currently member of the NIH Council of Councils. Dr. Ojeda has been continuously supported by NIH grants for over 30
PY - 2009
Y1 - 2009
N2 - Puberty is the phase in life when individuals become capable of reproducing. During puberty, major hormonal, physical, and behavioral changes take place. Changes occurring through puberty are accompanied by psychological modifications that significantly affect the role of individual members in society. Because the factor(s) that trigger puberty remains as a great mystery of our time, in this chapter the authors have approached this question systematically by analyzing the maturation of each component of the reproductive endocrine system and, in great detail, the developmental changes that occur in neurons and glia of the hypothalamus during reproductive maturation. Highlights of the chapter include discussion of: (1) the possible genes responsible for the onset of puberty, (2) a potential role of kisspeptin and its receptor GPR54 in the hypothalamic control of puberty, and (3) the maturation of neocortical and limbic circuits that determine the establishment of adolescent behaviors.
AB - Puberty is the phase in life when individuals become capable of reproducing. During puberty, major hormonal, physical, and behavioral changes take place. Changes occurring through puberty are accompanied by psychological modifications that significantly affect the role of individual members in society. Because the factor(s) that trigger puberty remains as a great mystery of our time, in this chapter the authors have approached this question systematically by analyzing the maturation of each component of the reproductive endocrine system and, in great detail, the developmental changes that occur in neurons and glia of the hypothalamus during reproductive maturation. Highlights of the chapter include discussion of: (1) the possible genes responsible for the onset of puberty, (2) a potential role of kisspeptin and its receptor GPR54 in the hypothalamic control of puberty, and (3) the maturation of neocortical and limbic circuits that determine the establishment of adolescent behaviors.
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U2 - 10.1016/B978-008088783-8.00064-4
DO - 10.1016/B978-008088783-8.00064-4
M3 - Chapter
AN - SCOPUS:84884776312
SN - 9780080887838
SP - 2035
EP - 2113
BT - Hormones, Brain and Behavior Online
PB - Elsevier Inc.
ER -