Neuroendocrine metastases to the ovaries are significantly associated with small bowel neuroendocrine tumors and carcinomatosis

Kristen E. Limbach, Su Ellen J. Pommier, Elizabeth Dewey, Enrique Leon, Rodney F. Pommier

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    Introduction: Neuroendocrine tumors (NETs) metastatic to the ovary are traditionally considered rare, but data are lacking. This study seeks to better characterize the prevalence and outcomes of patients with neuroendocrine ovarian metastases (NOM). Methods: Women with well-differentiated lung and gastroenteropancreatic NETs 2007–2017 were identified by medical record query. Clinicopathologic data were reviewed among patients with and without NOM. Results: Of 242 patients, 27 (11.2%) developed NOM. NOM developed in 24.8% of SBNET patients and 65.7% of patients with carcinomatosis and intact ovaries. 33.3% had associated small bowel obstructions; 11.1% had ureteral obstruction. NOM were not apparent on imaging in 29.6% nor visible intraoperatively in 8.3%. Five-year survival rate was 61.5%. Those who underwent oophorectomy had a lower rate of subsequent ureteral obstruction (p < 0.01). Conclusions: NOM are more prevalent than previously reported and associated with significant morbidity. Empiric oophorectomy may be considered for SBNET patients and strongly advised in carcinomatosis.

    Original languageEnglish (US)
    Pages (from-to)795-799
    Number of pages5
    JournalAmerican journal of surgery
    Volume219
    Issue number5
    DOIs
    StatePublished - May 2020

    Keywords

    • Carcinoid
    • Neuroendocrine tumors
    • Ovarian metastasis

    ASJC Scopus subject areas

    • Surgery

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