Neuroendocrine mechanisms controlling female puberty

New approaches, new concepts

Sergio Ojeda, Christian Roth, Alison Mungenast, Sabine Heger, Claudio Mastronardi, Anne Simone Parent, Alejandro Lomniczi, Heike Jung, J. Høgberg

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Sexual development and mature reproductive function are controlled by a handful of neurones that, located in the basal forebrain, produce the decapeptide luteinizing hormone releasing hormone (LHRH). LHRH is released into the portal system that connects the hypothalamus to the pituitary gland and act on the latter to stimulate the synthesis and release of gonadotrophin hormones. The pubertal activation of LHRH release requires coordinated changes in excitatory and inhibitory inputs to LHRH-secreting neurones. These inputs are provided by both transsynaptic and glia-to-neurone communication pathways. Using cellular and molecular approaches, in combination with transgenic animal models and high-throughput procedures for gene discovery, we are gaining new insight into the basic mechanisms underlying this dual control of LHRH secretion and, hence, the initiation of mammalian puberty. Our results suggest that the initiation of puberty requires reciprocal neurone-glia communication involving excitatory amino acids and growth factors, and the coordinated actions of a group of transcriptional regulators that appear to represent a higher level of control governing the pubertal process.

    Original languageEnglish (US)
    Pages (from-to)256-263
    Number of pages8
    JournalInternational Journal of Andrology
    Volume29
    Issue number1
    DOIs
    StatePublished - Feb 2006

    Fingerprint

    Puberty
    Gonadotropin-Releasing Hormone
    Neurons
    Neuroglia
    Communication
    Portal System
    Sexual Development
    Excitatory Amino Acids
    Genetically Modified Animals
    Genetic Association Studies
    Pituitary Gland
    Gonadotropins
    Hypothalamus
    Intercellular Signaling Peptides and Proteins
    Animal Models
    Hormones

    Keywords

    • Astroglial cells
    • Glial-neuronal communication
    • Growth factors
    • Hypothalamus
    • Onset of puberty
    • Sexual development

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Neuroendocrine mechanisms controlling female puberty : New approaches, new concepts. / Ojeda, Sergio; Roth, Christian; Mungenast, Alison; Heger, Sabine; Mastronardi, Claudio; Parent, Anne Simone; Lomniczi, Alejandro; Jung, Heike; Høgberg, J.

    In: International Journal of Andrology, Vol. 29, No. 1, 02.2006, p. 256-263.

    Research output: Contribution to journalArticle

    Ojeda, S, Roth, C, Mungenast, A, Heger, S, Mastronardi, C, Parent, AS, Lomniczi, A, Jung, H & Høgberg, J 2006, 'Neuroendocrine mechanisms controlling female puberty: New approaches, new concepts', International Journal of Andrology, vol. 29, no. 1, pp. 256-263. https://doi.org/10.1111/j.1365-2605.2005.00619.x
    Ojeda, Sergio ; Roth, Christian ; Mungenast, Alison ; Heger, Sabine ; Mastronardi, Claudio ; Parent, Anne Simone ; Lomniczi, Alejandro ; Jung, Heike ; Høgberg, J. / Neuroendocrine mechanisms controlling female puberty : New approaches, new concepts. In: International Journal of Andrology. 2006 ; Vol. 29, No. 1. pp. 256-263.
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