TY - JOUR
T1 - Neuroendocrine control of female puberty
T2 - Glial and neuronal interactions
AU - Ma, Ying J.
AU - Ojeda, Sergio R.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants HD25123 and
PY - 1997
Y1 - 1997
N2 - Emerging evidence suggests that, in addition to neuronal inputs, growth factors of glial origin are also important in the control of mammalian puberty via a cell-cell interaction that ultimately affects the neurons that release gonadotropin-releasing hormone (GnRH), a neurohormone controlling sexual development. Among these growth factors, transforming growth factor- α (TGFα) appears to be one of the physiologic components that controls the onset of female puberty by affecting GnRH nueuronal activity in a glia- mediated autocrine/paracrine manner. Specifically, TGFα induces glia to produce bioactive substances, such as prostaglandin E2 (PGE2). In turn, PGE2 directly acts on GnRH neurons to stimulate therelease of GnRH. Furthermore, the neuregulin of glial origin neu differentiation factor (NDF) was found to facilitate the action of TGFα, suggesting that other growth factors may exert their biologic effects on GnRH neuronal function via a glia/neuron interaction. Another indication that glial cells may be involved in the regulation of neuroendocrine function is the presence of estrogen receptors on hypothalamic astrocytes. Thus, region-specific glial cells appear to play an integral role in the regulation of neuroendocrine function.
AB - Emerging evidence suggests that, in addition to neuronal inputs, growth factors of glial origin are also important in the control of mammalian puberty via a cell-cell interaction that ultimately affects the neurons that release gonadotropin-releasing hormone (GnRH), a neurohormone controlling sexual development. Among these growth factors, transforming growth factor- α (TGFα) appears to be one of the physiologic components that controls the onset of female puberty by affecting GnRH nueuronal activity in a glia- mediated autocrine/paracrine manner. Specifically, TGFα induces glia to produce bioactive substances, such as prostaglandin E2 (PGE2). In turn, PGE2 directly acts on GnRH neurons to stimulate therelease of GnRH. Furthermore, the neuregulin of glial origin neu differentiation factor (NDF) was found to facilitate the action of TGFα, suggesting that other growth factors may exert their biologic effects on GnRH neuronal function via a glia/neuron interaction. Another indication that glial cells may be involved in the regulation of neuroendocrine function is the presence of estrogen receptors on hypothalamic astrocytes. Thus, region-specific glial cells appear to play an integral role in the regulation of neuroendocrine function.
KW - Astrocytes
KW - GnRH
KW - Growth factors
KW - Receptors
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U2 - 10.1038/jidsymp.1997.5
DO - 10.1038/jidsymp.1997.5
M3 - Article
C2 - 9487010
AN - SCOPUS:0030849399
SN - 1087-0024
VL - 2
SP - 19
EP - 22
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
IS - 1
ER -