Neuroendocrine control of female puberty

Glial and neuronal interactions

Ying J. Ma, Sergio Ojeda

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Emerging evidence suggests that, in addition to neuronal inputs, growth factors of glial origin are also important in the control of mammalian puberty via a cell-cell interaction that ultimately affects the neurons that release gonadotropin-releasing hormone (GnRH), a neurohormone controlling sexual development. Among these growth factors, transforming growth factor- α (TGFα) appears to be one of the physiologic components that controls the onset of female puberty by affecting GnRH nueuronal activity in a glia- mediated autocrine/paracrine manner. Specifically, TGFα induces glia to produce bioactive substances, such as prostaglandin E2 (PGE2). In turn, PGE2 directly acts on GnRH neurons to stimulate therelease of GnRH. Furthermore, the neuregulin of glial origin neu differentiation factor (NDF) was found to facilitate the action of TGFα, suggesting that other growth factors may exert their biologic effects on GnRH neuronal function via a glia/neuron interaction. Another indication that glial cells may be involved in the regulation of neuroendocrine function is the presence of estrogen receptors on hypothalamic astrocytes. Thus, region-specific glial cells appear to play an integral role in the regulation of neuroendocrine function.

    Original languageEnglish (US)
    Pages (from-to)19-22
    Number of pages4
    JournalJournal of Investigative Dermatology Symposium Proceedings
    Volume2
    Issue number1
    StatePublished - 1997

    Fingerprint

    Puberty
    Neuroglia
    Gonadotropin-Releasing Hormone
    Transforming Growth Factors
    Neuregulin-1
    Neurons
    Dinoprostone
    Intercellular Signaling Peptides and Proteins
    Neuregulins
    Sexual Development
    Cell Communication
    Astrocytes
    Estrogen Receptors
    Neurotransmitter Agents

    Keywords

    • Astrocytes
    • GnRH
    • Growth factors
    • Receptors

    ASJC Scopus subject areas

    • Dermatology

    Cite this

    Neuroendocrine control of female puberty : Glial and neuronal interactions. / Ma, Ying J.; Ojeda, Sergio.

    In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 2, No. 1, 1997, p. 19-22.

    Research output: Contribution to journalArticle

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