Neuroendocrine carcinoma of the pineal parenchyma. The first reported case

Melanie Hakar; James P. Chandler; Eileen H. Bigio; Qinwen Mao

doi:10.1016/j.jocn.2016.09.024

Neuroendocrine carcinoma of the pineal parenchyma. The first reported case

Melanie Hakar, James P. Chandler, Eileen H. Bigio, Qinwen Mao

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a case of a 35-year-old female patient who presented with worsening headaches, vertigo, and vision changes. MRI of the brain showed an enhancing lesion in the pineal region. The patient was taken for resection of the lesion which was classified as neuroendocrine carcinoma of the pineal parenchyma, intermediate grade. Histologically, the neoplasm was cellular, mitotically active, and composed of tightly packed cells with high nuclear cytoplasmic ratio, scant cytoplasm, and ill-defined cell borders. Immunohistochemically the tumor cells were positive for chromogranin, synaptophysin and AE1/AE3, and negative for CK-7, CK-20, and TTF1. Possible metastasis from any other primary sites was ruled out clinically. This represents the first reported case of neuroendocrine carcinoma of the pineal parenchyma.

Original language	English (US)
Pages (from-to)	68-70
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	35
DOIs	https://doi.org/10.1016/j.jocn.2016.09.024
State	Published - Jan 1 2017
Externally published	Yes

Keywords

Brain tumor
Neuroendocrine tumor
Pineal gland

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2016.09.024

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title = "Neuroendocrine carcinoma of the pineal parenchyma. The first reported case",

abstract = "We report a case of a 35-year-old female patient who presented with worsening headaches, vertigo, and vision changes. MRI of the brain showed an enhancing lesion in the pineal region. The patient was taken for resection of the lesion which was classified as neuroendocrine carcinoma of the pineal parenchyma, intermediate grade. Histologically, the neoplasm was cellular, mitotically active, and composed of tightly packed cells with high nuclear cytoplasmic ratio, scant cytoplasm, and ill-defined cell borders. Immunohistochemically the tumor cells were positive for chromogranin, synaptophysin and AE1/AE3, and negative for CK-7, CK-20, and TTF1. Possible metastasis from any other primary sites was ruled out clinically. This represents the first reported case of neuroendocrine carcinoma of the pineal parenchyma.",

keywords = "Brain tumor, Neuroendocrine tumor, Pineal gland",

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doi = "10.1016/j.jocn.2016.09.024",

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T1 - Neuroendocrine carcinoma of the pineal parenchyma. The first reported case

AU - Hakar, Melanie

AU - Chandler, James P.

AU - Bigio, Eileen H.

AU - Mao, Qinwen

PY - 2017/1/1

Y1 - 2017/1/1

N2 - We report a case of a 35-year-old female patient who presented with worsening headaches, vertigo, and vision changes. MRI of the brain showed an enhancing lesion in the pineal region. The patient was taken for resection of the lesion which was classified as neuroendocrine carcinoma of the pineal parenchyma, intermediate grade. Histologically, the neoplasm was cellular, mitotically active, and composed of tightly packed cells with high nuclear cytoplasmic ratio, scant cytoplasm, and ill-defined cell borders. Immunohistochemically the tumor cells were positive for chromogranin, synaptophysin and AE1/AE3, and negative for CK-7, CK-20, and TTF1. Possible metastasis from any other primary sites was ruled out clinically. This represents the first reported case of neuroendocrine carcinoma of the pineal parenchyma.

AB - We report a case of a 35-year-old female patient who presented with worsening headaches, vertigo, and vision changes. MRI of the brain showed an enhancing lesion in the pineal region. The patient was taken for resection of the lesion which was classified as neuroendocrine carcinoma of the pineal parenchyma, intermediate grade. Histologically, the neoplasm was cellular, mitotically active, and composed of tightly packed cells with high nuclear cytoplasmic ratio, scant cytoplasm, and ill-defined cell borders. Immunohistochemically the tumor cells were positive for chromogranin, synaptophysin and AE1/AE3, and negative for CK-7, CK-20, and TTF1. Possible metastasis from any other primary sites was ruled out clinically. This represents the first reported case of neuroendocrine carcinoma of the pineal parenchyma.

KW - Brain tumor

KW - Neuroendocrine tumor

KW - Pineal gland

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JF - Journal of Clinical Neuroscience

ER -

Neuroendocrine carcinoma of the pineal parenchyma. The first reported case

Abstract

Keywords

ASJC Scopus subject areas

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