Neurodevelopmental antecedents of early-onset bipolar affective disorder

Engilbert Sigurdsson, Eric Fombonne, Kapil Sayal, Stuart Checkley

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: Developmental impairments have been identified as a risk factor for early-onset schizophrenia. Affective symptoms are more common in children and adolescents with disordered neurodevelopment than in healthy controls. Aims: To test the hypothesis that severe early-onset mood disorders are associated with developmental antecedents. Method: We retrospectively identified 38 adolescent cases (15 female, 23 male; mean age 14.4 years, range 11-18) who met ICD-10 Research Diagnostic Criteria for a manic episode, bipolar affective disorder or psychotic depression, and 41 controls (25 female, 16 male, mean age 14.2 years, range 11-18) with depression but without psychotic features. Results: Cases were significantly more likely to have experienced delayed language, social or motor development (OR 5.5, 95% CI = 1.4-21.6, P = 0.01), in particular those who develop psychotic symptoms (OR 7.2, 95% CI = 1.8-28.6, P = 0.003). Conclusions: Compared to early-onset unipolar depression, neurodevelopmental antecedents are over-represented in early-onset bipolar disorder. The validity of this finding was supported by contemporaneous IQ scores that are not subject to the same potential biases as case-note ratings. Declaration of interest: None.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalBritish Journal of Psychiatry
Volume174
Issue numberFEB.
StatePublished - 1999
Externally publishedYes

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Mood Disorders
Bipolar Disorder
Depression
Affective Symptoms
International Classification of Diseases
Depressive Disorder
Schizophrenia
Language
Research
Major Affective Disorder 3

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Neurodevelopmental antecedents of early-onset bipolar affective disorder. / Sigurdsson, Engilbert; Fombonne, Eric; Sayal, Kapil; Checkley, Stuart.

In: British Journal of Psychiatry, Vol. 174, No. FEB., 1999, p. 121-127.

Research output: Contribution to journalArticle

Sigurdsson, E, Fombonne, E, Sayal, K & Checkley, S 1999, 'Neurodevelopmental antecedents of early-onset bipolar affective disorder', British Journal of Psychiatry, vol. 174, no. FEB., pp. 121-127.
Sigurdsson, Engilbert ; Fombonne, Eric ; Sayal, Kapil ; Checkley, Stuart. / Neurodevelopmental antecedents of early-onset bipolar affective disorder. In: British Journal of Psychiatry. 1999 ; Vol. 174, No. FEB. pp. 121-127.
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