TY - JOUR
T1 - Neurodevelopmental antecedents of early-onset bipolar affective disorder
AU - Sigurdsson, Engilbert
AU - Fombonne, Eric
AU - Sayal, Kapil
AU - Checkley, Stuart
PY - 1999
Y1 - 1999
N2 - Background: Developmental impairments have been identified as a risk factor for early-onset schizophrenia. Affective symptoms are more common in children and adolescents with disordered neurodevelopment than in healthy controls. Aims: To test the hypothesis that severe early-onset mood disorders are associated with developmental antecedents. Method: We retrospectively identified 38 adolescent cases (15 female, 23 male; mean age 14.4 years, range 11-18) who met ICD-10 Research Diagnostic Criteria for a manic episode, bipolar affective disorder or psychotic depression, and 41 controls (25 female, 16 male, mean age 14.2 years, range 11-18) with depression but without psychotic features. Results: Cases were significantly more likely to have experienced delayed language, social or motor development (OR 5.5, 95% CI = 1.4-21.6, P = 0.01), in particular those who develop psychotic symptoms (OR 7.2, 95% CI = 1.8-28.6, P = 0.003). Conclusions: Compared to early-onset unipolar depression, neurodevelopmental antecedents are over-represented in early-onset bipolar disorder. The validity of this finding was supported by contemporaneous IQ scores that are not subject to the same potential biases as case-note ratings. Declaration of interest: None.
AB - Background: Developmental impairments have been identified as a risk factor for early-onset schizophrenia. Affective symptoms are more common in children and adolescents with disordered neurodevelopment than in healthy controls. Aims: To test the hypothesis that severe early-onset mood disorders are associated with developmental antecedents. Method: We retrospectively identified 38 adolescent cases (15 female, 23 male; mean age 14.4 years, range 11-18) who met ICD-10 Research Diagnostic Criteria for a manic episode, bipolar affective disorder or psychotic depression, and 41 controls (25 female, 16 male, mean age 14.2 years, range 11-18) with depression but without psychotic features. Results: Cases were significantly more likely to have experienced delayed language, social or motor development (OR 5.5, 95% CI = 1.4-21.6, P = 0.01), in particular those who develop psychotic symptoms (OR 7.2, 95% CI = 1.8-28.6, P = 0.003). Conclusions: Compared to early-onset unipolar depression, neurodevelopmental antecedents are over-represented in early-onset bipolar disorder. The validity of this finding was supported by contemporaneous IQ scores that are not subject to the same potential biases as case-note ratings. Declaration of interest: None.
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U2 - 10.1192/bjp.174.2.121
DO - 10.1192/bjp.174.2.121
M3 - Article
C2 - 10211165
AN - SCOPUS:0032990791
SN - 0007-1250
VL - 174
SP - 121
EP - 127
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - FEB.
ER -