Abstract
Self-awareness (SA) is a cognitive ability to differentiate between self and non-self cues and is pivotal to understand the behavior of other human beings. For this reason, there has been a significant interest to investigate the neurobiology of SA in human subjects. So far the majority of such research has been conducted in healthy subjects but a significant relationship between impaired SA and poor psychosocial outcome in schizophrenia has stimulated neuroimaging research in this patient population. The results from small number of neuroimaging studies in schizophrenia suggest that impaired SA may be mediated by a dysfunction of cortical midline structures. This paper is an attempt to review emerging functional magnetic resonance imaging (fMRI) data in schizophrenia and to propose a hypothetical model of deficits in SA in schizophrenia that can be tested in future research. The model is refined from the available literature and proposes that self-referential activity appears to reflect a shift from activation of anterior to posterior cortical midline structures in schizophrenia subjects, which may be related to lack of functional connectivity between different cortical midline regions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-254 |
| Number of pages | 7 |
| Journal | Asian Journal of Psychiatry |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2011 |
| Externally published | Yes |
Fingerprint
Keywords
- Deficits
- Hypothetical
- Model
- Neurobiology
- Schizophrenia
- Self-awareness
ASJC Scopus subject areas
- Psychiatry and Mental health
- Psychology(all)
Cite this
Neurobiology of self-awareness deficits in schizophrenia : A hypothetical model. / Shad, Mujeeb; Brent, Benjamin K.; Keshavan, Matcheri S.
In: Asian Journal of Psychiatry, Vol. 4, No. 4, 12.2011, p. 248-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurobiology of self-awareness deficits in schizophrenia
T2 - A hypothetical model
AU - Shad, Mujeeb
AU - Brent, Benjamin K.
AU - Keshavan, Matcheri S.
PY - 2011/12
Y1 - 2011/12
N2 - Self-awareness (SA) is a cognitive ability to differentiate between self and non-self cues and is pivotal to understand the behavior of other human beings. For this reason, there has been a significant interest to investigate the neurobiology of SA in human subjects. So far the majority of such research has been conducted in healthy subjects but a significant relationship between impaired SA and poor psychosocial outcome in schizophrenia has stimulated neuroimaging research in this patient population. The results from small number of neuroimaging studies in schizophrenia suggest that impaired SA may be mediated by a dysfunction of cortical midline structures. This paper is an attempt to review emerging functional magnetic resonance imaging (fMRI) data in schizophrenia and to propose a hypothetical model of deficits in SA in schizophrenia that can be tested in future research. The model is refined from the available literature and proposes that self-referential activity appears to reflect a shift from activation of anterior to posterior cortical midline structures in schizophrenia subjects, which may be related to lack of functional connectivity between different cortical midline regions.
AB - Self-awareness (SA) is a cognitive ability to differentiate between self and non-self cues and is pivotal to understand the behavior of other human beings. For this reason, there has been a significant interest to investigate the neurobiology of SA in human subjects. So far the majority of such research has been conducted in healthy subjects but a significant relationship between impaired SA and poor psychosocial outcome in schizophrenia has stimulated neuroimaging research in this patient population. The results from small number of neuroimaging studies in schizophrenia suggest that impaired SA may be mediated by a dysfunction of cortical midline structures. This paper is an attempt to review emerging functional magnetic resonance imaging (fMRI) data in schizophrenia and to propose a hypothetical model of deficits in SA in schizophrenia that can be tested in future research. The model is refined from the available literature and proposes that self-referential activity appears to reflect a shift from activation of anterior to posterior cortical midline structures in schizophrenia subjects, which may be related to lack of functional connectivity between different cortical midline regions.
KW - Deficits
KW - Hypothetical
KW - Model
KW - Neurobiology
KW - Schizophrenia
KW - Self-awareness
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U2 - 10.1016/j.ajp.2011.09.002
DO - 10.1016/j.ajp.2011.09.002
M3 - Article
VL - 4
SP - 248
EP - 254
JO - Asian Journal of Psychiatry
JF - Asian Journal of Psychiatry
SN - 1876-2018
IS - 4
ER -