Neurobiology of decision-making in adolescents

Mujeeb Shad, Anup S. Bidesi, Li Ann Chen, Binu P. Thomas, Monique Ernst, Uma Rao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The study examined the relationship between risk-taking behavior during selection of monetary rewards and activations in the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC), brain regions that are associated with decision-making. Thirty-three adolescents with no personal or family history of any psychiatric illness were administered the Wheel of Fortune (WOF) task using a functional magnetic resonance imaging protocol. The WOF is a computerized two-choice, probabilistic monetary reward task. Selection of a reward, particularly a low-probability/high-magnitude reward choice, induced greater activations in dorsal ACC, ventrolateral OFC and mPFC than the control condition. Although similar findings have been reported by earlier studies, the results from this study were not impacted by reaction times and expected values and persisted even after controlling for sociodemographic factors. Post hoc analysis revealed greater activation of ACC and mPFC in response to selection of rewards of larger magnitude than those of smaller magnitude when the probability of reward was maintained constant. Adolescents with greater frequency of high-risk behavior (defined as low-probability/high-magnitude reward choice) had lower activation of ACC, OFC and mPFC than those who engaged in this behavior less frequently. These findings suggest individual differences in prefrontal cortical function with regards to decision-making process in adolescents.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalBehavioural Brain Research
Volume217
Issue number1
DOIs
StatePublished - Feb 2 2011
Externally publishedYes

Fingerprint

Neurobiology
Prefrontal Cortex
Reward
Decision Making
Gyrus Cinguli
Risk-Taking
Individuality
Reaction Time
Psychiatry
Magnetic Resonance Imaging
Brain

Keywords

  • Adolescents
  • Choice
  • Decision-making
  • Neurobiology
  • Rewards
  • Selection

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Shad, M., Bidesi, A. S., Chen, L. A., Thomas, B. P., Ernst, M., & Rao, U. (2011). Neurobiology of decision-making in adolescents. Behavioural Brain Research, 217(1), 67-76. https://doi.org/10.1016/j.bbr.2010.09.033

Neurobiology of decision-making in adolescents. / Shad, Mujeeb; Bidesi, Anup S.; Chen, Li Ann; Thomas, Binu P.; Ernst, Monique; Rao, Uma.

In: Behavioural Brain Research, Vol. 217, No. 1, 02.02.2011, p. 67-76.

Research output: Contribution to journalArticle

Shad, M, Bidesi, AS, Chen, LA, Thomas, BP, Ernst, M & Rao, U 2011, 'Neurobiology of decision-making in adolescents', Behavioural Brain Research, vol. 217, no. 1, pp. 67-76. https://doi.org/10.1016/j.bbr.2010.09.033
Shad, Mujeeb ; Bidesi, Anup S. ; Chen, Li Ann ; Thomas, Binu P. ; Ernst, Monique ; Rao, Uma. / Neurobiology of decision-making in adolescents. In: Behavioural Brain Research. 2011 ; Vol. 217, No. 1. pp. 67-76.
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