Neurobiology of decision-making in adolescents

Mujeeb U. Shad, Anup S. Bidesi, Li Ann Chen, Binu P. Thomas, Monique Ernst, Uma Rao

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    The study examined the relationship between risk-taking behavior during selection of monetary rewards and activations in the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC), brain regions that are associated with decision-making. Thirty-three adolescents with no personal or family history of any psychiatric illness were administered the Wheel of Fortune (WOF) task using a functional magnetic resonance imaging protocol. The WOF is a computerized two-choice, probabilistic monetary reward task. Selection of a reward, particularly a low-probability/high-magnitude reward choice, induced greater activations in dorsal ACC, ventrolateral OFC and mPFC than the control condition. Although similar findings have been reported by earlier studies, the results from this study were not impacted by reaction times and expected values and persisted even after controlling for sociodemographic factors. Post hoc analysis revealed greater activation of ACC and mPFC in response to selection of rewards of larger magnitude than those of smaller magnitude when the probability of reward was maintained constant. Adolescents with greater frequency of high-risk behavior (defined as low-probability/high-magnitude reward choice) had lower activation of ACC, OFC and mPFC than those who engaged in this behavior less frequently. These findings suggest individual differences in prefrontal cortical function with regards to decision-making process in adolescents.

    Original languageEnglish (US)
    Pages (from-to)67-76
    Number of pages10
    JournalBehavioural Brain Research
    Volume217
    Issue number1
    DOIs
    StatePublished - Feb 2 2011

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    Keywords

    • Adolescents
    • Choice
    • Decision-making
    • Neurobiology
    • Rewards
    • Selection

    ASJC Scopus subject areas

    • Behavioral Neuroscience

    Cite this

    Shad, M. U., Bidesi, A. S., Chen, L. A., Thomas, B. P., Ernst, M., & Rao, U. (2011). Neurobiology of decision-making in adolescents. Behavioural Brain Research, 217(1), 67-76. https://doi.org/10.1016/j.bbr.2010.09.033