Neurobiological correlates of behavioral and cognitive performance in nonhuman primates

Gwendolen E. Haley, Jacob Raber

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Animals in experiments are traditionally grouped by experimental treatment. Although this is a valuable way to differentiate the groups, alternatively, groups can be distinguished based on cognitive performance. Performance based analysis can yield valuable insights, corresponding to behavior and/or cognition, that might not otherwise be observed. As an example of such an analysis, we discuss a cohort of elderly female rhesus macaques who participated in a spatial food port maze navigational test. Circadian activity and pharmacological MRI (phMRI) were assessed in these monkeys in vivo and radioligand binding was assessed in post-mortem tissue. Based on cognitive performance in the spatial maze, the cohort of monkeys was divided into Good Spatial Performers (GSP) and Poor Spatial Performers (PSP). GSP animals were more active during the day and less active at night compared to PSP animals. In addition, GSP animals had a higher percentage change in blood-oxygen-level-dependent (BOLD) signal after a scopolamine challenge, a non-specific muscarinic receptor antagonist, compared to PSP animals. Post-mortem radioligand experiments demonstrated that hippocampal muscarinic type 1 (M1) maximum receptor binding and receptor binding affinity, hypothesized to have an integral role in spatial learning and memory, was significantly greater in the hippocampus of GSP than PSP animals. In contrast to the hippocampus, M1 receptor binding was not significantly different in the prefrontal cortex (PFC). Muscarinic type 2 (M2) maximum receptor binding and receptor binding affinity were not significantly different between the two groups in either brain region. Finally, there were positive correlations between circadian measures and the percentage change in BOLD signal following the scopolamine challenge, as well as M1 receptor binding measures. Thus, GSP animals sleep more and have anenhanced M1 receptor function. These data demonstrate the close relationship between BOLD signal changes, circadian activity, and M1 receptor binding parameters. Distinguishing groups based on cognitive or behavioral performance is valuable for studying neurobiological correlates of performance in nonhuman primates.

Original languageEnglish (US)
Title of host publicationPrimates: Classification, Evolution and Behavior
PublisherNova Science Publishers, Inc.
Pages135-157
Number of pages23
ISBN (Print)9781620814987
StatePublished - 2012

Fingerprint

cognition
Primates
Muscarinic Receptors
receptors
Scopolamine Hydrobromide
Oxygen
Cholinergic Agents
Haplorhini
scopolamine
Hippocampus
animals
hippocampus
oxygen
Muscarinic Antagonists
monkeys
blood
Prefrontal Cortex
Macaca mulatta
Cognition
Sleep

Keywords

  • Behavioral groups
  • Muscarinic receptors
  • PhMRI

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Haley, G. E., & Raber, J. (2012). Neurobiological correlates of behavioral and cognitive performance in nonhuman primates. In Primates: Classification, Evolution and Behavior (pp. 135-157). Nova Science Publishers, Inc..

Neurobiological correlates of behavioral and cognitive performance in nonhuman primates. / Haley, Gwendolen E.; Raber, Jacob.

Primates: Classification, Evolution and Behavior. Nova Science Publishers, Inc., 2012. p. 135-157.

Research output: Chapter in Book/Report/Conference proceedingChapter

Haley, GE & Raber, J 2012, Neurobiological correlates of behavioral and cognitive performance in nonhuman primates. in Primates: Classification, Evolution and Behavior. Nova Science Publishers, Inc., pp. 135-157.
Haley GE, Raber J. Neurobiological correlates of behavioral and cognitive performance in nonhuman primates. In Primates: Classification, Evolution and Behavior. Nova Science Publishers, Inc. 2012. p. 135-157
Haley, Gwendolen E. ; Raber, Jacob. / Neurobiological correlates of behavioral and cognitive performance in nonhuman primates. Primates: Classification, Evolution and Behavior. Nova Science Publishers, Inc., 2012. pp. 135-157
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