Neurobehavioral effects of methyl bromide inhalation exposures

Wyndham Anger, J. V. Setzer, J. M. Russo, W. S. Brightwell, R. G. Wait, B. L. Johnson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Methyl bromide, a neurotoxic agent with a permissible US exposure limit of 20 ppm, is used primarily as a fumigant by an estimated 75,000 workers in the United States. This project was developed to evaluate the neurobehavioral effects of chronic and subchronic exposure to methyl bromide. One group of rats and rabbits was exposed to 65 ppm of methyl bromide for a total exposure of 4 25-hr weeks, or 100 hr, and rats were exposed to 55 ppm of methyl bromide for a total exposure of 36 30-hr weeks, or 1,080 hr. Comparable control groups were given similar treatment, but no exposure. Behavioral tests of open field activity and limb coordination were conducted weekly during both phases of the experiment with rats, and eye-blink reflexes were measured weekly in rabbits. Nerve conduction velocity measurements were taken weekly from both rats and rabbits during the 65-ppm 4-week exposures and monthly from rats during the 55-ppm 40-week exposures. Exposure to 65 ppm for 4 weeks significantly reduced eyeblink responses and nerve conduction velocity in rabbits but had no effect on rats. Exposure to 55 ppm of methyl bromide for 36 weeks had no effect on nerve conduction velocity, open-field activity, or coordination in rats.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalScandinavian Journal of Work, Environment and Health
Volume7
Issue numberSuppl. 4
StatePublished - 1981
Externally publishedYes

Fingerprint

methyl bromide
Inhalation Exposure
Rats
Neural Conduction
Rabbits
worker
experiment
Blinking
fumigant
exposure
effect
Velocity measurement
Group

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

Cite this

Anger, W., Setzer, J. V., Russo, J. M., Brightwell, W. S., Wait, R. G., & Johnson, B. L. (1981). Neurobehavioral effects of methyl bromide inhalation exposures. Scandinavian Journal of Work, Environment and Health, 7(Suppl. 4), 40-47.

Neurobehavioral effects of methyl bromide inhalation exposures. / Anger, Wyndham; Setzer, J. V.; Russo, J. M.; Brightwell, W. S.; Wait, R. G.; Johnson, B. L.

In: Scandinavian Journal of Work, Environment and Health, Vol. 7, No. Suppl. 4, 1981, p. 40-47.

Research output: Contribution to journalArticle

Anger, W, Setzer, JV, Russo, JM, Brightwell, WS, Wait, RG & Johnson, BL 1981, 'Neurobehavioral effects of methyl bromide inhalation exposures', Scandinavian Journal of Work, Environment and Health, vol. 7, no. Suppl. 4, pp. 40-47.
Anger W, Setzer JV, Russo JM, Brightwell WS, Wait RG, Johnson BL. Neurobehavioral effects of methyl bromide inhalation exposures. Scandinavian Journal of Work, Environment and Health. 1981;7(Suppl. 4):40-47.
Anger, Wyndham ; Setzer, J. V. ; Russo, J. M. ; Brightwell, W. S. ; Wait, R. G. ; Johnson, B. L. / Neurobehavioral effects of methyl bromide inhalation exposures. In: Scandinavian Journal of Work, Environment and Health. 1981 ; Vol. 7, No. Suppl. 4. pp. 40-47.
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