Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit

J. M. Russo, Wyndham Anger, J. V. Setzer, W. S. Brightwell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neurobehavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long-term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6-8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible.

Original languageEnglish (US)
Pages (from-to)247-255
Number of pages9
JournalJournal of Toxicology and Environmental Health
Volume14
Issue number2-3
StatePublished - 1984
Externally publishedYes

Fingerprint

methyl bromide
Rabbits
Blinking
Recovery
Muscle
Animals
Ulnar Nerve
Sciatic Nerve
Inhalation
Body Weight
Weights and Measures
Muscles
Research

ASJC Scopus subject areas

  • Pollution
  • Toxicology

Cite this

Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit. / Russo, J. M.; Anger, Wyndham; Setzer, J. V.; Brightwell, W. S.

In: Journal of Toxicology and Environmental Health, Vol. 14, No. 2-3, 1984, p. 247-255.

Research output: Contribution to journalArticle

@article{e64adeca567648aeadf482d9d09767db,
title = "Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit",
abstract = "The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neurobehavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long-term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6-8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible.",
author = "Russo, {J. M.} and Wyndham Anger and Setzer, {J. V.} and Brightwell, {W. S.}",
year = "1984",
language = "English (US)",
volume = "14",
pages = "247--255",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "0098-4108",
publisher = "Taylor and Francis Ltd.",
number = "2-3",

}

TY - JOUR

T1 - Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit

AU - Russo, J. M.

AU - Anger, Wyndham

AU - Setzer, J. V.

AU - Brightwell, W. S.

PY - 1984

Y1 - 1984

N2 - The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neurobehavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long-term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6-8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible.

AB - The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neurobehavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long-term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6-8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible.

UR - http://www.scopus.com/inward/record.url?scp=0021715846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021715846&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 247

EP - 255

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 0098-4108

IS - 2-3

ER -