Neuroadaptive responses to chronic ethanol

Kari Buck, R. A. Harris

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA-activated chloride channels, voltage-sensitive calcium channels, NMDA-activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalAlcoholism: Clinical and Experimental Research
Volume15
Issue number3
StatePublished - 1991
Externally publishedYes

Fingerprint

Ethanol
Chloride Channels
Guanine Nucleotides
N-Methylaspartate
Calcium Channels
Membrane Lipids
Gene expression
gamma-Aminobutyric Acid
Cations
Carrier Proteins
Tissue
Gene Expression
Electric potential

Keywords

  • Dependence
  • Ethanol
  • GABA
  • Ion channels
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Neuroadaptive responses to chronic ethanol. / Buck, Kari; Harris, R. A.

In: Alcoholism: Clinical and Experimental Research, Vol. 15, No. 3, 1991, p. 460-470.

Research output: Contribution to journalArticle

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