Neuroadaptive Responses to Chronic Ethanol

Kari J. Buck; R. Adron Harris

doi:10.1111/j.1530-0277.1991.tb00544.x

Neuroadaptive Responses to Chronic Ethanol

Kari J. Buck, R. Adron Harris

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA‐activated chloride channels, voltage‐sensitive calcium channels, NMDA‐activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.

Original language	English (US)
Pages (from-to)	460-470
Number of pages	11
Journal	Alcoholism: Clinical and Experimental Research
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/j.1530-0277.1991.tb00544.x
State	Published - Jun 1991
Externally published	Yes

Keywords

Dependence
Ethanol
GABA
Ion Channels
Tolerance

ASJC Scopus subject areas

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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10.1111/j.1530-0277.1991.tb00544.x

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abstract = "Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA‐activated chloride channels, voltage‐sensitive calcium channels, NMDA‐activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.",

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AU - Harris, R. Adron

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AB - Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA‐activated chloride channels, voltage‐sensitive calcium channels, NMDA‐activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.

KW - Dependence

KW - Ethanol

KW - GABA

KW - Ion Channels

KW - Tolerance

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Neuroadaptive Responses to Chronic Ethanol

Abstract

Keywords

ASJC Scopus subject areas

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