Neuroadaptive Responses to Chronic Ethanol

Kari J. Buck, R. Adron Harris

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA‐activated chloride channels, voltage‐sensitive calcium channels, NMDA‐activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalAlcoholism: Clinical and Experimental Research
Volume15
Issue number3
DOIs
StatePublished - Jun 1991

Keywords

  • Dependence
  • Ethanol
  • GABA
  • Ion Channels
  • Tolerance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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