Neural stem cell niches: Roles for the hyaluronan-based extracellular matrix

Marnie Preston, Lawrence (Larry) Sherman

    Research output: Contribution to journalArticle

    71 Citations (Scopus)

    Abstract

    Neural stem/progenitor cells capable of differentiating into the neurons and glial cells that populate the mammalian central nervous system (CNS) persist in specific neural stem cell niches that regulate stem cell proliferation, survival and differentiation. There is growing evidence that the extracellular matrix within neural stem cell niches is required for neural stem cell maintenance. Here, we review findings supporting a pivotal role for the glycosaminoglycan hyaluronan (HA) and its transmembrane receptors in neural stem/progenitor cell proliferation, differentiation and maturation. We also outline findings supporting changing roles for HA as cells become committed to distinct lineages in the brain and spinal cord.

    Original languageEnglish (US)
    Pages (from-to)1165-1179
    Number of pages15
    JournalFrontiers in Bioscience - Scholar
    Volume3 S
    Issue number3
    StatePublished - Jan 6 2011

    Fingerprint

    Stem Cell Niche
    Neural Stem Cells
    Hyaluronic Acid
    Stem cells
    Extracellular Matrix
    Stem Cells
    Cell proliferation
    Cell Differentiation
    Cell Proliferation
    Glycosaminoglycans
    Neuroglia
    Neurology
    Cell Survival
    Spinal Cord
    Central Nervous System
    Neurons
    Maintenance
    Brain

    Keywords

    • Hyaluronan
    • Neural Stem Cell Niches
    • Review
    • Subgranular Zone
    • Subventricular Zone
    • Ventricular Zone

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Immunology and Microbiology(all)
    • Medicine(all)

    Cite this

    Neural stem cell niches : Roles for the hyaluronan-based extracellular matrix. / Preston, Marnie; Sherman, Lawrence (Larry).

    In: Frontiers in Bioscience - Scholar, Vol. 3 S, No. 3, 06.01.2011, p. 1165-1179.

    Research output: Contribution to journalArticle

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