Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

David B. Averill, William E. Cameron, Albert J. Berger

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain research
Volume346
Issue number2
DOIs
StatePublished - Nov 4 1985

Keywords

  • cross-correlation
  • dorsal respiratory group
  • inspiratory neuron
  • spike-triggered averaging

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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