Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

David B. Averill; William E. Cameron; Albert J. Berger

doi:10.1016/0006-8993(85)90874-1

Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

David B. Averill, William E. Cameron, Albert J. Berger

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Abstract

The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.

Original language	English (US)
Pages (from-to)	378-382
Number of pages	5
Journal	Brain research
Volume	346
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(85)90874-1
State	Published - Nov 4 1985

Keywords

cross-correlation
dorsal respiratory group
inspiratory neuron
spike-triggered averaging

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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@article{dcc7d27126a240f7a93cd547c23233fa,

title = "Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons",

abstract = "The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.",

keywords = "cross-correlation, dorsal respiratory group, inspiratory neuron, spike-triggered averaging",

author = "Averill, {David B.} and Cameron, {William E.} and Berger, {Albert J.}",

note = "Funding Information: The authors express their appreciation to William Satterthwaite for his technical assistance and to Hanna Atkins for her help in preparing the illustrations and manuscript. This research was supported by USPHS Research Grant NS 14857 and by Grant RR-00374 for the computational facility. D.B.A. and W.E.C. were supported by NRSA postdoctoral fellowships HL-06233 and HL-06474, respectively.",

year = "1985",

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doi = "10.1016/0006-8993(85)90874-1",

language = "English (US)",

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pages = "378--382",

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T1 - Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

AU - Averill, David B.

AU - Cameron, William E.

AU - Berger, Albert J.

N1 - Funding Information: The authors express their appreciation to William Satterthwaite for his technical assistance and to Hanna Atkins for her help in preparing the illustrations and manuscript. This research was supported by USPHS Research Grant NS 14857 and by Grant RR-00374 for the computational facility. D.B.A. and W.E.C. were supported by NRSA postdoctoral fellowships HL-06233 and HL-06474, respectively.

PY - 1985/11/4

Y1 - 1985/11/4

N2 - The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.

AB - The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.

KW - cross-correlation

KW - dorsal respiratory group

KW - inspiratory neuron

KW - spike-triggered averaging

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SP - 378

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JO - Brain Research

JF - Brain Research

SN - 0006-8993

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ER -

Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

Abstract

Keywords

ASJC Scopus subject areas

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