Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons

David B. Averill, William Cameron, Albert J. Berger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The neural elements responsible for facilitation of phrenic nerve activity by lung inflation were investigated in cats by the simultaneous recording of individual pulmonary stretch receptor afferents, respiratory neurons of the ventrolateral nucleus of the tractus solitarius and phrenic nerve activity. Monosynaptic excitation of Iβ neurons by slowly adapting pulmonary stretch receptors was demonstrated by cross-correlational analysis. It was also demonstrated that the majority of these same Iβ neurons projected to the contralateral C5 phrenic motoneuron pool. Thus, this study has shown that Iβ neurons can act as central neural elements to mediate the facilitatory effect of lung inflation upon phrenic nerve activity.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain Research
Volume346
Issue number2
DOIs
StatePublished - Nov 4 1985
Externally publishedYes

Fingerprint

Pulmonary Stretch Receptors
Phrenic Nerve
Motor Neurons
Diaphragm
Economic Inflation
Neurons
Afferent Neurons
Lung
Solitary Nucleus
Cats

Keywords

  • cross-correlation
  • dorsal respiratory group
  • inspiratory neuron
  • spike-triggered averaging

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons. / Averill, David B.; Cameron, William; Berger, Albert J.

In: Brain Research, Vol. 346, No. 2, 04.11.1985, p. 378-382.

Research output: Contribution to journalArticle

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