TY - JOUR
T1 - Neural control of fasting-induced torpor in mice
AU - Hitrec, Timna
AU - Luppi, Marco
AU - Bastianini, Stefano
AU - Squarcio, Fabio
AU - Berteotti, Chiara
AU - Lo Martire, Viviana
AU - Martelli, Davide
AU - Occhinegro, Alessandra
AU - Tupone, Domenico
AU - Zoccoli, Giovanna
AU - Amici, Roberto
AU - Cerri, Matteo
N1 - Funding Information:
This research was supported by funding from the University of Bologna (RFO 2018) and the European Space Agency (Research agreement collaboration 4000123556). The author wish to thank Ms. Melissa Stott for reviewing the English, and Dr. Arrigo Bondi, former director of the Operative Unit of Pathologic Anatomy, Ospedale Maggiore, Bologna (Italy), for making available a fluorescence microscope.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the activation of all thermogenic organs that could potentially defend body temperature must be prevented. Most of these organs, such as the brown adipose tissue, are controlled by the key thermoregulatory region of the Raphe Pallidus (RPa). Currently, it is not known which brain areas mediate the entrance into torpor. To identify these areas, the expression of the early gene c-Fos at torpor onset was assessed in different brain regions in mice injected with a retrograde tracer (Cholera Toxin subunit b, CTb) into the RPa region. The results show a network of hypothalamic neurons that are specifically activated at torpor onset and a direct torpor-specific projection from the Dorsomedial Hypothalamus to the RPa that could putatively mediate the suppression of thermogenesis during torpor.
AB - Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the activation of all thermogenic organs that could potentially defend body temperature must be prevented. Most of these organs, such as the brown adipose tissue, are controlled by the key thermoregulatory region of the Raphe Pallidus (RPa). Currently, it is not known which brain areas mediate the entrance into torpor. To identify these areas, the expression of the early gene c-Fos at torpor onset was assessed in different brain regions in mice injected with a retrograde tracer (Cholera Toxin subunit b, CTb) into the RPa region. The results show a network of hypothalamic neurons that are specifically activated at torpor onset and a direct torpor-specific projection from the Dorsomedial Hypothalamus to the RPa that could putatively mediate the suppression of thermogenesis during torpor.
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U2 - 10.1038/s41598-019-51841-2
DO - 10.1038/s41598-019-51841-2
M3 - Article
C2 - 31664081
AN - SCOPUS:85074250763
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 15462
ER -