Neural control of behavioral and molecular defenses in C. elegans

Jogender Singh, Alejandro Aballay

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The nervous and immune systems use bi-directional communication to control host responses against microbial pathogens. Recent studies at the interface of the two systems have highlighted important roles of the nervous system in the regulation of both microbicidal pathways and pathogen avoidance behaviors. Studies on the neural circuits in the simple model host Caenorhabditis elegans have significantly improved our understanding of the roles of conserved neural mechanisms in controlling innate immunity. Moreover, behavioral studies have advanced our understanding of how the nervous system may sense potential pathogens and consequently elicit pathogen avoidance, reducing the risk of infection. In this review, we discuss the neural circuits that regulate both behavioral immunity and molecular immunity in C. elegans.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume62
DOIs
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Neuroscience(all)

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