Networks of coactive neurons in developing layer 1

Theodore H. Schwartz, Daniel Rabinowitz, Vivek Unni, Vikram S. Kumar, Diana K. Smetters, Areti Tsiola, Rafael Yuste

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Spontaneous neuronal activity plays an important role in the development of cortical circuitry, yet its spatio-temporal dynamics are poorly understood. Cajal-Retziua (CR) neurons in developing layer I are necessary for correct cortical lamination and are strategically located to coordinate early circuit activity. To characterize the spontaneous activity of CR and other layer I neurons during cortical development, we imaged calcium transients in populations of layer 1 neurons in hemispheres and slices from postnatal rat somatosensory neocortex. The spontaneous activity in layer 1 had complex spatio-temporal patterns. Groups of non-CR cells showed synchronous activations and formed networks of correlated neurons superimposed in the same territory. Correlated activity among non-CR cells was mediated by a depolarizing effect of GABA and was modulated by glutamate, probably released by CR cells. Our findings demonstrate that developing layer 1 can sustain complex patterns of correlated activity and reveal a circuit mechanism that can mediate this patterned activity.

Original languageEnglish (US)
Pages (from-to)541-552
Number of pages12
JournalNeuron
Volume20
Issue number3
DOIs
StatePublished - Mar 1998
Externally publishedYes

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Neurons
Neocortex
gamma-Aminobutyric Acid
Glutamic Acid
Calcium
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Schwartz, T. H., Rabinowitz, D., Unni, V., Kumar, V. S., Smetters, D. K., Tsiola, A., & Yuste, R. (1998). Networks of coactive neurons in developing layer 1. Neuron, 20(3), 541-552. https://doi.org/10.1016/S0896-6273(00)80993-9

Networks of coactive neurons in developing layer 1. / Schwartz, Theodore H.; Rabinowitz, Daniel; Unni, Vivek; Kumar, Vikram S.; Smetters, Diana K.; Tsiola, Areti; Yuste, Rafael.

In: Neuron, Vol. 20, No. 3, 03.1998, p. 541-552.

Research output: Contribution to journalArticle

Schwartz, TH, Rabinowitz, D, Unni, V, Kumar, VS, Smetters, DK, Tsiola, A & Yuste, R 1998, 'Networks of coactive neurons in developing layer 1', Neuron, vol. 20, no. 3, pp. 541-552. https://doi.org/10.1016/S0896-6273(00)80993-9
Schwartz TH, Rabinowitz D, Unni V, Kumar VS, Smetters DK, Tsiola A et al. Networks of coactive neurons in developing layer 1. Neuron. 1998 Mar;20(3):541-552. https://doi.org/10.1016/S0896-6273(00)80993-9
Schwartz, Theodore H. ; Rabinowitz, Daniel ; Unni, Vivek ; Kumar, Vikram S. ; Smetters, Diana K. ; Tsiola, Areti ; Yuste, Rafael. / Networks of coactive neurons in developing layer 1. In: Neuron. 1998 ; Vol. 20, No. 3. pp. 541-552.
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