Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism

M. Fukuda, M. J. Mentis, Y. Ma, V. Dhawan, A. Antonini, A. E. Lang, A. M. Lozano, John Hammerstad, K. Lyons, W. C. Koller, J. R. Moeller, D. Eidelberg

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Employing [ 18F]fluorodeoxyglucose (FDG) and PET, we have found previously that stereotaxic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic changes in brain regions remote from the lesion site. In this study we determined whether similar metabolic changes occur in Parkinson's disease patients treated with deep brain stimulation (DBS) of the GPi. We studied seven Parkinson's disease patients with FDG-PET to measure resting regional cerebral glucose utilization on and off GPi stimulation. We used statistical parametric mapping to identify significant changes in regional brain metabolism that occurred with this intervention. We also quantified stimulation-related changes in the expression of a specific abnormal Parkinson's disease-related pattern of metabolic covariation (PDRP) that had been identified in earlier FDG-PET studies. Metabolic changes with DBS were correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (UPDRS) motor ratings off medication. GPi DBS improved UPDRS motor ratings (36%, P <0.001) and significantly increased regional glucose metabolism in the premotor cortex ipsilateral to stimulation and in the cerebellum bilaterally. GPi DBS also resulted in a significant (P <0.01) decline in PDRP activity ipsilateral to stimulation, which correlated significantly with clinical improvement in UPDRS motor ratings (P <0.03). Clinical improvement with GPi DBS is associated with reduced expression of an abnormal Parkinson's disease-related metabolic network involving elements of the cortico-striato-pallido-thalamocortical and the cerebello-cortical motor loops.

Original languageEnglish (US)
Pages (from-to)1601-1609
Number of pages9
JournalBrain
Volume124
Issue number8
StatePublished - 2001

Fingerprint

Parkinson Disease
Globus Pallidus
Deep Brain Stimulation
Glucose
Brain
Fluorodeoxyglucose F18
Motor Cortex
Metabolic Networks and Pathways
Cerebellum

Keywords

  • [ F]fluorodeoxyglucose
  • Brain networks
  • Deep brain stimulation
  • Parkinson's disease
  • PET

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fukuda, M., Mentis, M. J., Ma, Y., Dhawan, V., Antonini, A., Lang, A. E., ... Eidelberg, D. (2001). Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism. Brain, 124(8), 1601-1609.

Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism. / Fukuda, M.; Mentis, M. J.; Ma, Y.; Dhawan, V.; Antonini, A.; Lang, A. E.; Lozano, A. M.; Hammerstad, John; Lyons, K.; Koller, W. C.; Moeller, J. R.; Eidelberg, D.

In: Brain, Vol. 124, No. 8, 2001, p. 1601-1609.

Research output: Contribution to journalArticle

Fukuda, M, Mentis, MJ, Ma, Y, Dhawan, V, Antonini, A, Lang, AE, Lozano, AM, Hammerstad, J, Lyons, K, Koller, WC, Moeller, JR & Eidelberg, D 2001, 'Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism', Brain, vol. 124, no. 8, pp. 1601-1609.
Fukuda, M. ; Mentis, M. J. ; Ma, Y. ; Dhawan, V. ; Antonini, A. ; Lang, A. E. ; Lozano, A. M. ; Hammerstad, John ; Lyons, K. ; Koller, W. C. ; Moeller, J. R. ; Eidelberg, D. / Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism. In: Brain. 2001 ; Vol. 124, No. 8. pp. 1601-1609.
@article{0f53fbaab9d04d6fbe28f5d8a252e278,
title = "Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism",
abstract = "Employing [ 18F]fluorodeoxyglucose (FDG) and PET, we have found previously that stereotaxic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic changes in brain regions remote from the lesion site. In this study we determined whether similar metabolic changes occur in Parkinson's disease patients treated with deep brain stimulation (DBS) of the GPi. We studied seven Parkinson's disease patients with FDG-PET to measure resting regional cerebral glucose utilization on and off GPi stimulation. We used statistical parametric mapping to identify significant changes in regional brain metabolism that occurred with this intervention. We also quantified stimulation-related changes in the expression of a specific abnormal Parkinson's disease-related pattern of metabolic covariation (PDRP) that had been identified in earlier FDG-PET studies. Metabolic changes with DBS were correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (UPDRS) motor ratings off medication. GPi DBS improved UPDRS motor ratings (36{\%}, P <0.001) and significantly increased regional glucose metabolism in the premotor cortex ipsilateral to stimulation and in the cerebellum bilaterally. GPi DBS also resulted in a significant (P <0.01) decline in PDRP activity ipsilateral to stimulation, which correlated significantly with clinical improvement in UPDRS motor ratings (P <0.03). Clinical improvement with GPi DBS is associated with reduced expression of an abnormal Parkinson's disease-related metabolic network involving elements of the cortico-striato-pallido-thalamocortical and the cerebello-cortical motor loops.",
keywords = "[ F]fluorodeoxyglucose, Brain networks, Deep brain stimulation, Parkinson's disease, PET",
author = "M. Fukuda and Mentis, {M. J.} and Y. Ma and V. Dhawan and A. Antonini and Lang, {A. E.} and Lozano, {A. M.} and John Hammerstad and K. Lyons and Koller, {W. C.} and Moeller, {J. R.} and D. Eidelberg",
year = "2001",
language = "English (US)",
volume = "124",
pages = "1601--1609",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease. A PET study of resting-state glucose metabolism

AU - Fukuda, M.

AU - Mentis, M. J.

AU - Ma, Y.

AU - Dhawan, V.

AU - Antonini, A.

AU - Lang, A. E.

AU - Lozano, A. M.

AU - Hammerstad, John

AU - Lyons, K.

AU - Koller, W. C.

AU - Moeller, J. R.

AU - Eidelberg, D.

PY - 2001

Y1 - 2001

N2 - Employing [ 18F]fluorodeoxyglucose (FDG) and PET, we have found previously that stereotaxic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic changes in brain regions remote from the lesion site. In this study we determined whether similar metabolic changes occur in Parkinson's disease patients treated with deep brain stimulation (DBS) of the GPi. We studied seven Parkinson's disease patients with FDG-PET to measure resting regional cerebral glucose utilization on and off GPi stimulation. We used statistical parametric mapping to identify significant changes in regional brain metabolism that occurred with this intervention. We also quantified stimulation-related changes in the expression of a specific abnormal Parkinson's disease-related pattern of metabolic covariation (PDRP) that had been identified in earlier FDG-PET studies. Metabolic changes with DBS were correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (UPDRS) motor ratings off medication. GPi DBS improved UPDRS motor ratings (36%, P <0.001) and significantly increased regional glucose metabolism in the premotor cortex ipsilateral to stimulation and in the cerebellum bilaterally. GPi DBS also resulted in a significant (P <0.01) decline in PDRP activity ipsilateral to stimulation, which correlated significantly with clinical improvement in UPDRS motor ratings (P <0.03). Clinical improvement with GPi DBS is associated with reduced expression of an abnormal Parkinson's disease-related metabolic network involving elements of the cortico-striato-pallido-thalamocortical and the cerebello-cortical motor loops.

AB - Employing [ 18F]fluorodeoxyglucose (FDG) and PET, we have found previously that stereotaxic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic changes in brain regions remote from the lesion site. In this study we determined whether similar metabolic changes occur in Parkinson's disease patients treated with deep brain stimulation (DBS) of the GPi. We studied seven Parkinson's disease patients with FDG-PET to measure resting regional cerebral glucose utilization on and off GPi stimulation. We used statistical parametric mapping to identify significant changes in regional brain metabolism that occurred with this intervention. We also quantified stimulation-related changes in the expression of a specific abnormal Parkinson's disease-related pattern of metabolic covariation (PDRP) that had been identified in earlier FDG-PET studies. Metabolic changes with DBS were correlated with clinical improvement as measured by changes in Unified Parkinson's Disease Rating Scale (UPDRS) motor ratings off medication. GPi DBS improved UPDRS motor ratings (36%, P <0.001) and significantly increased regional glucose metabolism in the premotor cortex ipsilateral to stimulation and in the cerebellum bilaterally. GPi DBS also resulted in a significant (P <0.01) decline in PDRP activity ipsilateral to stimulation, which correlated significantly with clinical improvement in UPDRS motor ratings (P <0.03). Clinical improvement with GPi DBS is associated with reduced expression of an abnormal Parkinson's disease-related metabolic network involving elements of the cortico-striato-pallido-thalamocortical and the cerebello-cortical motor loops.

KW - [ F]fluorodeoxyglucose

KW - Brain networks

KW - Deep brain stimulation

KW - Parkinson's disease

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0034901447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034901447&partnerID=8YFLogxK

M3 - Article

VL - 124

SP - 1601

EP - 1609

JO - Brain

JF - Brain

SN - 0006-8950

IS - 8

ER -